CAJ | 학술논문

目的：观察甘露聚糖肽联合奈达铂胸腔内灌注治疗恶性胸腔积液的疗效。方法将94例恶性胸腔积液患者随机分为两组，观察组48例采用甘露聚糖肽+奈达铂胸腔内灌注，对照组46例单纯采用奈达铂灌注。治疗后观察两组的有效率及不良反应发生情况。结果观察组有效率(85.4豫)高于对照组(69.6豫)(P<0.05)；观察组胃肠道反应、骨髓抑制及胸痛发生率分别为35.4豫、22.9%和18.8豫，与对照组比较明显降低，两组比较差异有统计学意义(P<0.05)。结论甘露聚糖肽联合奈达铂治疗恶性胸腔积液有效率高，不良反应少，值得临床推广。
목적：관찰감로취당태연합내체박흉강내관주치료악성흉강적액적료효。방법장94례악성흉강적액환자수궤분위량조，관찰조48례채용감로취당태+내체박흉강내관주，대조조46례단순채용내체박관주。치료후관찰량조적유효솔급불량반응발생정황。결과관찰조유효솔(85.4예)고우대조조(69.6예)(P<0.05)；관찰조위장도반응、골수억제급흉통발생솔분별위35.4예、22.9%화18.8예，여대조조비교명현강저，량조비교차이유통계학의의(P<0.05)。결론감로취당태연합내체박치료악성흉강적액유효솔고，불량반응소，치득림상추엄。
Objective To observe the efficacy of mannatide injection and nedaplatin injected in thoracic cavity in the treatment of malignant pleural effusion. Methods Ninety-four patients with malignant pleural effusion were randomly divided into two groups. The observation group of 48 patients were given mannatide injection and nedaplatin,and con-trol group of 46 patients were given only nedaplatin. Effectiveness and adverse reactions were observed after treatment. Results The effective rate was 85.4% in observation group, hihger than that in control group (69.6%)(P<0.05); The incidence rates of gastrointestinal tract and bone marrow and chest pain of observation group were 35.4%,22.9% and 18.8%. Compared with control group, the incidence of observation group had significantly lowered. There were signifi-cant differences between the two groups(P<0.05). Conclusion Mannatide injection combined with nedaplatin is more efficient and less adverse reaction for malignant pleural effusion, so it is worth popularizing.