CAJ | 학술논문

目的：探讨戈舍瑞林与孕三烯酮用于子宫内膜异位症术后疗效。方法75例腹腔镜下子宫内膜异位囊肿剥除术患者，根据治疗方法不同分为观察组37例和对照组38例。观察组术后1周内皮下注射戈舍瑞林3.6 mg，每4周1次，连用6次；对照组术后1周内口服孕三烯酮2.5 mg，每周2次，连用48次。治疗后随访2年，观察两组疗效及复发率、不良反应发生率和妊娠率。结果随访2年，对照组和观察组分别失访4例和2例，两组失访率比较差异无统计学意义(χ2=0.15，P>0.05)。观察组总有效率明显优于对照组，复发率明显低于对照组(χ2=3.85，P<0.05)。对照组和观察组分别发生不良反应9例和6例，症状均较轻微，两组不良反应发生率比较差异无统计学意义(χ2=0.88，P>0.05)。观察组停药后2年妊娠成功率明显高于对照组(χ2=4.69，P<0.05)。结论戈舍瑞林用于子宫内膜异位症术后较孕三烯酮具有更好疗效，能降低术后复发率，提高妊娠成功率，安全性较好。
목적：탐토과사서림여잉삼희동용우자궁내막이위증술후료효。방법75례복강경하자궁내막이위낭종박제술환자，근거치료방법불동분위관찰조37례화대조조38례。관찰조술후1주내피하주사과사서림3.6 mg，매4주1차，련용6차；대조조술후1주내구복잉삼희동2.5 mg，매주2차，련용48차。치료후수방2년，관찰량조료효급복발솔、불량반응발생솔화임신솔。결과수방2년，대조조화관찰조분별실방4례화2례，량조실방솔비교차이무통계학의의(χ2=0.15，P>0.05)。관찰조총유효솔명현우우대조조，복발솔명현저우대조조(χ2=3.85，P<0.05)。대조조화관찰조분별발생불량반응9례화6례，증상균교경미，량조불량반응발생솔비교차이무통계학의의(χ2=0.88，P>0.05)。관찰조정약후2년임신성공솔명현고우대조조(χ2=4.69，P<0.05)。결론과사서림용우자궁내막이위증술후교잉삼희동구유경호료효，능강저술후복발솔，제고임신성공솔，안전성교호。
Objective To discuss postoperative curative effect comparison of goserelin and gestrinone on endometriosis (EMT). Methods A total of 75 cases of patients with EMT, who were given EMT cystectomy of under laparoscopy, were divided into observation group (n=37 cases) and control group (n=38 cases) in accordance with different treatment meth-ods. The patients in observation group were given 3.6 mg goserelin by subcutaneous injection within 1 week upon the operation, once for every 4 weeks, for 6 times, while the patients in control group were given 2.5 mg gestrinone through the mouth within 1 week upon the operation, twice for every week for 48 times. According to the 2-year following-ups after treatment, the curative effect, reoccurrence rates, occurrence rates of untoward effect and pregnancy rates of pa-tients in two groups were observed. Results According to the 2-year following-ups after treatment, 4 and 2 cases of patients were lost to follow up, and after comparing the loss ratios of follow-up of patients in two groups, no statistical differences were appeared (χ2=0.15, P>0.05). The total efficiency of patients in observation group was much higher than that in control group, while the reoccurrence rate was much lower than that in control group (χ2=3.85, P<0.05). 9 and 6 cases of untoward effect were appeared in control group and observation group respectively, with light symptom, and after comparing the occurrence rates of untoward effect, no statistical differences were appeared (χ2=0.88,P>0.05). The suc-cessful pregnancy rate of patients in observation group after 2-year withdrawal of drugs was much higher than that in control group (χ2=4.69, P<0.05). Conclusion Compared with gestrinone, goserelin has more favorable postoperative cura-tive effect on EMT, which can obviously reduce the postoperative reoccurrence rate, and raise the successful pregnancy rate and higher security.