CAJ | 학술논문

目的：评价雾化吸入与静脉滴注喜炎平注射液治疗儿童呼吸道感染疾病的疗效与安全性。方法计算机检索Medline、Embase、Cochrane 图书馆临床对照试验资料库、CNKI、维普及万方数据库，纳入喜炎平注射液雾化吸入与静脉滴注治疗儿童感染性疾病的文献报道，并进行方法学质量评价和采用RevMan 5．0软件进行Meta分析。结果6项研究经Meta分析合并后结果显示，喜炎平注射液雾化给药组痊愈率与有效率均优于静脉滴注给药组，OR（95％CI）分别为2．28（1．48，3．53）与4．76（2．77，8．19）；在咽痛减轻时间、发热消退时间、咳嗽减轻时间方面比较差异均无统计学意义。结论现有的临床证据表明，雾化吸入喜炎平注射液治疗儿童呼吸道感染疗效优于静脉给药组，但由于本系统评价纳入研究证据强度不高，且样本量小，故上述结论尚需更多高质量RCT进一步验证。
목적：평개무화흡입여정맥적주희염평주사액치료인동호흡도감염질병적료효여안전성。방법계산궤검색Medline、Embase、Cochrane 도서관림상대조시험자료고、CNKI、유보급만방수거고，납입희염평주사액무화흡입여정맥적주치료인동감염성질병적문헌보도，병진행방법학질량평개화채용RevMan 5．0연건진행Meta분석。결과6항연구경Meta분석합병후결과현시，희염평주사액무화급약조전유솔여유효솔균우우정맥적주급약조，OR（95％CI）분별위2．28（1．48，3．53）여4．76（2．77，8．19）；재인통감경시간、발열소퇴시간、해수감경시간방면비교차이균무통계학의의。결론현유적림상증거표명，무화흡입희염평주사액치료인동호흡도감염료효우우정맥급약조，단유우본계통평개납입연구증거강도불고，차양본량소，고상술결론상수경다고질량RCT진일보험증。
Objective It is to evaluate the effectiveness and safety of aerosol inhalation and intravenous drip of Xiyanping injection for treatment of pediatric respiratory disease in children .Methods The randomized controlled trials of aerosol inhala-tion and intravenous drip of Xiyanping injection for treatment of pediatric respiratory disease in children were gathered from PubMed, Embase, and Cochrane database of Systematic Reviews , CNKI, VIP and Wanfang database .The assessment of method quality and Meta analysis were performed according to Cochrane Collaboration ’ s software RevMan 5.0.Results Six studies were included and the results showed that the clinical cure rates and clinical effective rates in the treatment with Xiyan -ping injection by aerosol inhalation were both better than that by intravenous drip ;OR (95%CI) were 2.28(1.48 to 3.53) and 4.76 (2.77 to 8.19) respectively.The sore throat relief time, fever clearance time, and cough relief time were no statis-tically different between the two groups .Conclusion According to the current evidence , aerosol inhalation of Xiyanping is more effective in the treatment of children with pediatric respiratory disease than versus intravenous drip of the injection .How-ever, because of the trials selected in this systematic review with lower evidence level and less sample size , more high quality clinical trials are need for further study .