CAJ | 학술논문

目的：观察空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症的临床疗效，并探讨其治疗机制。方法将符合纳入标准的54例患者随机分为2组，治疗组30例采用空气动力波联合前列地尔治疗，对照组28例仅采用前列地尔治疗，治疗2个疗程后评定2组临床疗效，并观察治疗前后下肢动脉血管内径、血流量及踝肱指数的变化情况。结果治疗2个疗程后，治疗组疗效优于对照组（P＜0．05）；治疗组下肢血管内径、血流量、踝肱指数改善程度均优于对照组（P均＜0．05）。结论空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症安全有效，其疗效优于单一前列地尔治疗。
목적：관찰공기동력파연합전렬지이치료당뇨병하지동맥경화증적림상료효，병탐토기치료궤제。방법장부합납입표준적54례환자수궤분위2조，치료조30례채용공기동력파연합전렬지이치료，대조조28례부채용전렬지이치료，치료2개료정후평정2조림상료효，병관찰치료전후하지동맥혈관내경、혈류량급과굉지수적변화정황。결과치료2개료정후，치료조료효우우대조조（P＜0．05）；치료조하지혈관내경、혈류량、과굉지수개선정도균우우대조조（P균＜0．05）。결론공기동력파연합전렬지이치료당뇨병하지동맥경화증안전유효，기료효우우단일전렬지이치료。
Objective It is to observe the clinical efficacy of aerodynamic wave plus Alprostadil on diabetic lower limb ar -teriosclerosis obliterans ,and to explore its mechanism .Methods 54 patients with diabetic lower limb arteriosclerosis obliterans were randomly allocated to treatment groups of 34 cases and control groups of 20 cases, the treatment group were treated with Aerodynamic wave plus Alprostadil , the control group were treated with Alprostadil only .After two treatment courses , the clin-ical curative effects of both groups were assessed , and the changes of blood vessel diameter of lower extremity artery , blood flow and ankle brachial index ( ABI) before and after treatment were observed .Results After two treatment courses , the cura-tive effect of treatment group was better than that of control group (P<0.05), and the improvements of blood vessel diameter of lower extremity artery, blood flow and ABI were also better than those of control group (P<0.05).Conclusion Aerody-namic wave plus Alprostadil is effective and safe in the treatment for diabetic lower limb arteriosclerosis obliterans .Its effect is superior to that of treatment with Alprostadil only .