CAJ | 학술논문

目的：观察人参皂苷联合糖皮质激素防治肾病综合征（ NS）的临床疗效，验证人参皂苷增强糖皮质激素效应的观点。方法将120例NS患者随机分为A组和B组，在常规泼尼松治疗的基础上，A组给予人参皂苷胶囊50 mg/次，2次/d口服，B组给予安慰剂胶囊50 mg/次，2次/d口服，疗程均为12个月。观察2组治疗前后中医临床症状、肝肾功能、血脂、血浆白蛋白、24 h尿蛋白定量变化情况及激素的减量情况和临床总体疗效。结果 A组总体临床疗效明显优于B组（ P＜00．5）；在降低24 h尿蛋白定量、减轻糖皮质激素不良反应方面效果较B组明显（P均＜0．05）；泼尼松减量幅度较B组明显（P＜0．05）。结论人参皂苷可以增强糖皮质激素治疗NS的临床效应，减少糖皮质激素的临床用量。
목적：관찰인삼조감연합당피질격소방치신병종합정（ NS）적림상료효，험증인삼조감증강당피질격소효응적관점。방법장120례NS환자수궤분위A조화B조，재상규발니송치료적기출상，A조급여인삼조감효낭50 mg/차，2차/d구복，B조급여안위제효낭50 mg/차，2차/d구복，료정균위12개월。관찰2조치료전후중의림상증상、간신공능、혈지、혈장백단백、24 h뇨단백정량변화정황급격소적감량정황화림상총체료효。결과 A조총체림상료효명현우우B조（ P＜00．5）；재강저24 h뇨단백정량、감경당피질격소불량반응방면효과교B조명현（P균＜0．05）；발니송감량폭도교B조명현（P＜0．05）。결론인삼조감가이증강당피질격소치료NS적림상효응，감소당피질격소적림상용량。
Objective It is to observe the clinical effect of Ginsenosides combining with glucocorticoid on nephritic syn -drome ( NS) , and to verify the view point that Ginsenosides could strengthen the effect of glucocorticoid .Methods 120 pa-tients with NS were randomly divided into group A and group B .On the basis of routine treatment with prednisone , Group A was given Ginsenosides capsule , and group B was given placebo capsule , both the drugs were given 50mg by oral administra-tion twice each day.Both the treatment courses were 12 months.The changes of traditional Chinese medicine symptoms , hepa-torenal function , blood fats, blood plasma albumin and 24 hour urine protein quota before and after treatment , dosage decre-ment of prednisone and clinical effect were observed in both groups .Results The total clinical curative effect in group A was significantly better than that in group B (P<0.05), while the effects of decreasing 24h hour urine protein quota and relieving side effects of glucocorticoid were better than those in group B (P<0.05), dosage decrement of prednisone was more than that in group B (P<0 .05).ConclusionGinsenosides maybe strengthen the clinical effect of glucocorticoid on NS , and decrease glucocorticoid usage .