中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
30期
44-45
,共2页
程燕%周恒根%李亚莉%倪敬中
程燕%週恆根%李亞莉%倪敬中
정연%주항근%리아리%예경중
腹腔灌注化疗%晚期胃癌%疗效
腹腔灌註化療%晚期胃癌%療效
복강관주화료%만기위암%료효
Intraperitoneal perfusion chemotherapy%Advanced gastric cancer%Curative effect
目的：探讨腹腔灌注化疗药物治疗晚期胃癌的临床疗效。方法：2011年1月-2012年12月收治晚期胃癌患者40例，随机分成对照组和观察组各20例，对照组采用5-氟尿嘧啶500 mg/m2，d 1～5；亚叶酸钙200 mg，d 1～5；奥沙利铂130 mg/m2，d 1化疗6周期，进行治疗。观察组采用5-氟尿嘧啶术后腹腔灌注+奥沙利铂进行治疗。结果：观察组完全缓解3例，部分缓解12例，稳定4例，进展1例，总有效率75.0%；对照组完全缓解1例，部分缓解6例，稳定8例，进展5例，总有效率35.0%，两组比较有统计学意义(P＜0.05)。观察组复发4例，转移14例，死亡2例，死亡率10.0%；对照组复发6例，转移8例，死亡6例，死亡率30.0%，两组死亡率比较差异有统计学意义(P＜0.05)。结论：腹腔灌注化疗治疗晚期胃癌可以明显降低死亡率，提高了临床疗效，值得临床推广。
目的：探討腹腔灌註化療藥物治療晚期胃癌的臨床療效。方法：2011年1月-2012年12月收治晚期胃癌患者40例，隨機分成對照組和觀察組各20例，對照組採用5-氟尿嘧啶500 mg/m2，d 1～5；亞葉痠鈣200 mg，d 1～5；奧沙利鉑130 mg/m2，d 1化療6週期，進行治療。觀察組採用5-氟尿嘧啶術後腹腔灌註+奧沙利鉑進行治療。結果：觀察組完全緩解3例，部分緩解12例，穩定4例，進展1例，總有效率75.0%；對照組完全緩解1例，部分緩解6例，穩定8例，進展5例，總有效率35.0%，兩組比較有統計學意義(P＜0.05)。觀察組複髮4例，轉移14例，死亡2例，死亡率10.0%；對照組複髮6例，轉移8例，死亡6例，死亡率30.0%，兩組死亡率比較差異有統計學意義(P＜0.05)。結論：腹腔灌註化療治療晚期胃癌可以明顯降低死亡率，提高瞭臨床療效，值得臨床推廣。
목적：탐토복강관주화료약물치료만기위암적림상료효。방법：2011년1월-2012년12월수치만기위암환자40례，수궤분성대조조화관찰조각20례，대조조채용5-불뇨밀정500 mg/m2，d 1～5；아협산개200 mg，d 1～5；오사리박130 mg/m2，d 1화료6주기，진행치료。관찰조채용5-불뇨밀정술후복강관주+오사리박진행치료。결과：관찰조완전완해3례，부분완해12례，은정4례，진전1례，총유효솔75.0%；대조조완전완해1례，부분완해6례，은정8례，진전5례，총유효솔35.0%，량조비교유통계학의의(P＜0.05)。관찰조복발4례，전이14례，사망2례，사망솔10.0%；대조조복발6례，전이8례，사망6례，사망솔30.0%，량조사망솔비교차이유통계학의의(P＜0.05)。결론：복강관주화료치료만기위암가이명현강저사망솔，제고료림상료효，치득림상추엄。
Objective:To explore the clinical effect of intraperitoneal perfusion chemotherapy drugs in the treatment of advanced gastric cancer.Methods:40 patients with advanced gastric cancer were selected from January 2011 to December 2012.They were randomly divided into the control group and the observation group with 20 cases in each.The control group were treated with 5-fluorouracil 500 mg/m2,d 1~5;calcium folinate 200 mg,d 1~5;oxaliplatin 130 mg/m2,d1 chemotherapy for 6 cycles.The observation group were treated with 5-fluorouracil postoperative intraperitoneal perfusion and oxaliplatin.Results:In the observation group,3 cases were complete remission;12 cases were partial remission;4 cases were no change;1 case was progressive disease;the total effective rate was 75.0%.In the control group,1 case was complete remission;6 cases were partial remission;8 cases were no change;5 cases were progressive disease;the total effective rate was 35.0% .The two groups was statistically significant(P<0.05).In the observation group,4 cases were relapse;14 cases were transfer;2 cases were death;the death rate was 10.0%.In the control group,6 cases were relapse;8 cases were transfer;6 cases were death;the death rate was 30.0%.The difference of two groups were statistically significant(P<0.05).Conclusion:Intraperitoneal perfusion chemotherapy in the treatment of advanced gastric cancer can obviously decrease the mortality,and improve the clinical curative effect.It is worthy of the clinical promotion.
