CAJ | 학술논문

目的：探讨急性冠脉综合征(ACS)患者在经皮冠脉介入治疗(PCI)手术前使用负荷剂量的瑞舒伐他汀和辛伐他汀对围术期cTnI、hs-CRP及心血管事件发生的影响。方法：收治急性冠脉综合征患者68例，随机分为瑞舒伐他汀组(冠脉造影前给予30 mg瑞舒伐他汀)和辛伐他汀组(冠脉造影前给予60 mg辛伐他汀)各34例。临床观察两组患者PCI术前后cTnI、hs-CRP变化情况；术后30 d及6个月的心血管不良事件(MACE)发生率。结果：瑞舒伐他汀组比辛伐他汀组术后30 d及6个月的MACE发生率低；PCI术后心肌损伤发生率低；PCI术后炎症因子增高幅度小。结论：对于急性冠脉综合征患者，瑞舒伐他汀比辛伐他汀具有更好的抗炎作用、心肌保护作用；同时可以明显降低 PCI 术后MACE的发生率。
목적：탐토급성관맥종합정(ACS)환자재경피관맥개입치료(PCI)수술전사용부하제량적서서벌타정화신벌타정대위술기cTnI、hs-CRP급심혈관사건발생적영향。방법：수치급성관맥종합정환자68례，수궤분위서서벌타정조(관맥조영전급여30 mg서서벌타정)화신벌타정조(관맥조영전급여60 mg신벌타정)각34례。림상관찰량조환자PCI술전후cTnI、hs-CRP변화정황；술후30 d급6개월적심혈관불량사건(MACE)발생솔。결과：서서벌타정조비신벌타정조술후30 d급6개월적MACE발생솔저；PCI술후심기손상발생솔저；PCI술후염증인자증고폭도소。결론：대우급성관맥종합정환자，서서벌타정비신벌타정구유경호적항염작용、심기보호작용；동시가이명현강저 PCI 술후MACE적발생솔。
Objective:To explore the effect of loading dose of rosuvastatin and simvastatin on the occurrence of perioperative cTnI, hs-CRP and cardiovascular events of patients with acute coronary syndrome before percutaneous coronary intervention operation. Methods:68 patients with acute coronary syndrome were selected.They were randomly divided into the rosuvastatin group(30 mg rosuvastatin was given before coronary angiography) and the simvastatin group(30 mg simvastatin was given before coronary angiography) with 34 patients in each group.We observed the changes of cTnI,hs-CRP before and after PCI of the two groups,and the adverse cardiovascular events(MACE) rate at 30 days after operation and 6 months.Results:Compared with the simvastatin group,in the fluvastatin group,at 30 days after operation and 6 months,the incidence rate of MACE was lower;after PCI,myocardial injury rate was low;after PCI,inflammatory cytokines increased amplitude was small.Conclusion:For patients with acute coronary syndrome,compared with simvastatin,rosuvastatin had better anti-inflammatory effect and myocardial protection effect,at the same time,it can significantly reduce the incidence of MACE after PCI.