现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
MODERN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
31期
3447-3449
,共3页
益气复脉胶囊%肺源性心脏病%心力衰竭%炎症%氧化应激
益氣複脈膠囊%肺源性心髒病%心力衰竭%炎癥%氧化應激
익기복맥효낭%폐원성심장병%심력쇠갈%염증%양화응격
Yiqifumai capsule%pulmonary heart disease%heart failure%inflammation%oxidative stress
目的：观察益气复脉胶囊治疗慢性肺源性心脏病心力衰竭（肺心病心衰）的临床疗效。方法将97例肺心病心衰患者随机分为益气复脉组（ n＝54）与对照组（ n＝43）。所有患者均接受化痰、平喘、抗感染、抗心衰等常规治疗，益气复脉组在此治疗基础上加用益气复脉胶囊治疗。观察2组临床疗效，比较治疗前后心功能、血气分析、血清炎症因子与氧化应激水平。结果益气复脉组总有效率明显高于对照组（ P＜0．05）。治疗后，2组患者心功能好转，低氧血症及酸中毒得到纠正，机体炎症因子及氧化应激水平显著下降（P均＜0．05），且益气复脉组改善更明显（P均＜0．05），但不能进一步减缓心率（P＞0．05）。整个研究中未发现药物不良反应。结论益气复脉胶囊可以明显改善慢性肺心病心衰患者的心肺功能，降低体内炎症因子与氧化应激水平，效果满意。
目的：觀察益氣複脈膠囊治療慢性肺源性心髒病心力衰竭（肺心病心衰）的臨床療效。方法將97例肺心病心衰患者隨機分為益氣複脈組（ n＝54）與對照組（ n＝43）。所有患者均接受化痰、平喘、抗感染、抗心衰等常規治療，益氣複脈組在此治療基礎上加用益氣複脈膠囊治療。觀察2組臨床療效，比較治療前後心功能、血氣分析、血清炎癥因子與氧化應激水平。結果益氣複脈組總有效率明顯高于對照組（ P＜0．05）。治療後，2組患者心功能好轉，低氧血癥及痠中毒得到糾正，機體炎癥因子及氧化應激水平顯著下降（P均＜0．05），且益氣複脈組改善更明顯（P均＜0．05），但不能進一步減緩心率（P＞0．05）。整箇研究中未髮現藥物不良反應。結論益氣複脈膠囊可以明顯改善慢性肺心病心衰患者的心肺功能，降低體內炎癥因子與氧化應激水平，效果滿意。
목적：관찰익기복맥효낭치료만성폐원성심장병심력쇠갈（폐심병심쇠）적림상료효。방법장97례폐심병심쇠환자수궤분위익기복맥조（ n＝54）여대조조（ n＝43）。소유환자균접수화담、평천、항감염、항심쇠등상규치료，익기복맥조재차치료기출상가용익기복맥효낭치료。관찰2조림상료효，비교치료전후심공능、혈기분석、혈청염증인자여양화응격수평。결과익기복맥조총유효솔명현고우대조조（ P＜0．05）。치료후，2조환자심공능호전，저양혈증급산중독득도규정，궤체염증인자급양화응격수평현저하강（P균＜0．05），차익기복맥조개선경명현（P균＜0．05），단불능진일보감완심솔（P＞0．05）。정개연구중미발현약물불량반응。결론익기복맥효낭가이명현개선만성폐심병심쇠환자적심폐공능，강저체내염증인자여양화응격수평，효과만의。
Objective It is to observe the clinical efficacy of Yiqifumai capsule on chronic pulmonary heart disease (CPHD) with heart failure.Methods 97 CPHD patients were randomly divided into 2 groups:Yiqifumai treatment group (n=54) and conventional treatment group ( n=43).All patients received the conventional treatments , including: expectorant, antiasthmatic , anti-inflammatory and heart failure treatment .In addition, Yanhuning treatment group also received Yanhun-ing capsule.The clinical curative effects were observed and several indics including :heart function, blood-gas analysis, lev-els of serum inflammation and oxidative stress before and after treatment in both groups were compared .Results The total ef-fective rate in Yiqifumai group was significantly higher than that in control group (P<0.05).After treatment, improved car-diac function, corrected hypoxemia and acidosis were occurred in both groups .At the same time, the levels of serum inflam-mation and oxidative stress were all decreased significantly (P<0.05).Compared with the control group , Yiqifumai group showed a better curative effect (P<0.05), but could not slow the heart rate (P>0.05).Adverse drug reaction was not found in the study .Conclusion Yiqifumai capsule could improve heart and lung function , reduce the levels of serum inflam-mation and oxidative stress in the patients with CPHD , the clinical curative effect is satisfied .
