CAJ | 학술논문

NOD样受体(NLRs)是细胞内感应器,能对各种不同的病原体和细胞内危险信号作出应答,从而诱导固有免疫反应.NLRC5是该家族成员之一,目前已经证实NLRC5是核转录因子κB、Ⅰ型干扰素、炎性体信号路径及MHC-I基因表达的重要调节器,在固有免疫反应和适应性免疫反应中发挥举足轻重的作用.本文就NLRC5的相关研究作一综述.
NOD양수체(NLRs)시세포내감응기,능대각충불동적병원체화세포내위험신호작출응답,종이유도고유면역반응.NLRC5시해가족성원지일,목전이경증실NLRC5시핵전록인자κB、Ⅰ형간우소、염성체신호로경급MHC-I기인표체적중요조절기,재고유면역반응화괄응성면역반응중발휘거족경중적작용.본문취NLRC5적상관연구작일종술.
Nod-like receptors (NLRs) are intracellular sensors that respond to a variety of pathogen and intracellular danger signals to induce innate immune responses.NLRC5,a number of NLRs family,has recently been identified to be an important regulator of nuclear factor-κB,type Ⅰ interferon,inflammation signaling pathways,and the expression of MHC class Ⅰ genes.It plays a pivotal role in the innate immune responses and adaptive immune responses.This paper summarizes the latest researches about NLRC5.