CAJ | 학술논문

以天然可生物降解高分子壳聚糖为原料，通过在壳聚糖氨基上引入辛基作为疏水基，在羟基上引入琥珀酸酐作为亲水基，形成具有两亲性的壳聚糖．通过红外、紫外和差热法对最终产物进行了表征，证实疏水基团和亲水基团成功引入壳聚糖．芘荧光探针法测定产物临界胶束质量浓度(CMC)为0.072,mg/mL．双亲修饰的壳聚糖可在水中形成胶束且具有pH敏感性．紫外透光率和粒径联合评价其pH响应范围为4.5～5.5．
이천연가생물강해고분자각취당위원료，통과재각취당안기상인입신기작위소수기，재간기상인입호박산항작위친수기，형성구유량친성적각취당．통과홍외、자외화차열법대최종산물진행료표정，증실소수기단화친수기단성공인입각취당．비형광탐침법측정산물림계효속질량농도(CMC)위0.072,mg/mL．쌍친수식적각취당가재수중형성효속차구유pH민감성．자외투광솔화립경연합평개기pH향응범위위4.5～5.5．
An amphipathic chitosan was synthesized using hydrophobic and hydrophilic chitosans prepared by grafting octyl and carboxyl benzoyl groups onto the natural biodegradable polymer chitosan. The chemical structure of galactosylated chi-tosan was characterized by FTIR,UVS,DSC,and proved the successful grafting of hydrophobic group and hydrophilic group onto the chitosan. The CMC of the chitosan derivatives was determinated to be 0.072mg/mL by Pyrene fluorescence probe method. The pH sensitivity of the pH-sensitive chitosan was evaluated by the ultraviolet-infrared spectrometer and particle size instrument,and the results showed that the range of the pH-sensitivity was 4.5-5.5.