CAJ | 학술논문

目的：评价临床药师对子宫肌瘤切除术患者围手术期抗菌药物应用进行干预的效果。方法：分别抽取该院2012年7-12月（干预前）和2013年1-6月（干预后）子宫肌瘤切除术出院患者病历共100份，对围手术期预防性应用抗菌药物的合理性进行比较。结果：干预后子宫肌瘤切除术围手术期患者预防性用药在药物选择、用药疗程、药物经济学方面较干预前有明显改善。干预前与干预后使用头孢菌素的比例分别为42.0%和72.0%；抗菌药物用药疗程合理率由12.0%升至60.0%，药物经济学合理率由50.0%升至86.0%，差异具有统计学意义（P <0.05）；总药品费用占住院总费用的比例由51.0%降至49.3%，抗菌药物总费用占总药品费用的比例由30.2%降至28.8%；患者人均住院天数下降1.26 d。结论：临床药师对围术期预防应用抗菌药物进行干预的方法是可行且有效的，能提高医院抗菌药物的合理使用水平，减少患者的住院时间和住院费用，对临床安全、有效、经济的应用抗菌药物起到了积极作用。
목적：평개림상약사대자궁기류절제술환자위수술기항균약물응용진행간예적효과。방법：분별추취해원2012년7-12월（간예전）화2013년1-6월（간예후）자궁기류절제술출원환자병력공100빈，대위수술기예방성응용항균약물적합이성진행비교。결과：간예후자궁기류절제술위수술기환자예방성용약재약물선택、용약료정、약물경제학방면교간예전유명현개선。간예전여간예후사용두포균소적비례분별위42.0%화72.0%；항균약물용약료정합리솔유12.0%승지60.0%，약물경제학합리솔유50.0%승지86.0%，차이구유통계학의의（P <0.05）；총약품비용점주원총비용적비례유51.0%강지49.3%，항균약물총비용점총약품비용적비례유30.2%강지28.8%；환자인균주원천수하강1.26 d。결론：림상약사대위술기예방응용항균약물진행간예적방법시가행차유효적，능제고의원항균약물적합리사용수평，감소환자적주원시간화주원비용，대림상안전、유효、경제적응용항균약물기도료적겁작용。
Objective:To estimate the intervention effects by clinical pharmacist on the use of antibacterials during perioperative period of myomectomy. Methods:The clinical data were collected from 50 patients with myomectomy from July to December in 2012 (before intervention) and 50 patients from January to June in 2013 (after intervention). The rationality of antibacterials application was evaluated thereafter. Results:After intervention by clinical pharmacists, the perioperative prophylactic application of antibacterials for myomectomy signiifcantly improved in respect of antibacterials selection, medication duration and pharmacoeconomics. Before and after intervention, the percentages of cephalosporins use were 42.0% and 72.0%, respectively. The reasonable rate of medication duration of antibacterials rose from 12.0%to 60.0%, the reasonable rate of pharmacoeconomics rose from 50.0%to 86.0%, with statistical signiifcance (P<0.05). The proportion of the total drug cost accounting for the total cost of hospitalization decreased from 51.0% to 49.3%, and the percentage of total antibacterials expense in the total medicine expense decreased from 30.2%to 28.8%. The mean hospitalization stay per patient decreased 1.26 days. Conclusion:The clinical pharmacists' intervention on the prophylactic application of antibacterials was feasible and effective, which can improve the rational application of antibacterials, decrease hospitalization stay and expense. It will promote safe, effective and economical use of antibacterials.