CAJ | 학술논문

1例气管腺样囊腺癌术后患者超剂量使用盐酸曲马多后出现气喘和气急症状。临床药师通过对其进行重点药学监护，查阅国内外相关文献，发现超剂量（＞1000 mg·d-1）或肝功能受损患者使用盐酸曲马多后可能会出现呼吸系统症状，表现为气喘、气急以及呼吸抑制症状。并对曲马多药理学机制及其不良反应处置、体内药代动力学特点等进行分析。患者停用曲马多后，气喘、气急症状得以缓解。
1례기관선양낭선암술후환자초제량사용염산곡마다후출현기천화기급증상。림상약사통과대기진행중점약학감호，사열국내외상관문헌，발현초제량（＞1000 mg·d-1）혹간공능수손환자사용염산곡마다후가능회출현호흡계통증상，표현위기천、기급이급호흡억제증상。병대곡마다약이학궤제급기불량반응처치、체내약대동역학특점등진행분석。환자정용곡마다후，기천、기급증상득이완해。
One tracheal adenoid cystic carcinoma patient after surgical operation developed asthma and shortness of breath because of over dose use of tramadol hydrochloride. The clinical pharmacists took pharmaceutical care for this speciifc case. According to literature from domestic and aboard, the patient using high dose of tramadol (>1000 mg·d-1) or the patient using tramadol with liver injury could develop asthma, shortness of breath and respiratory depression symptoms. The pharmacists discussed the pharmacology and pharmacokinetics of tramadol and treatment of adverse drug reaction caused by tramadol with doctors. Symptoms of asthma and shortness of breath eventually relieved after withdrawal of tramadol.