CAJ | 학술논문

围产期患者由于体内发生一系列生理变化，会影响药物在体内的动力学改变，且用药后存在胎盘转运和乳汁转运，可影响胎儿组织器官的发育及功能，新生儿对药物的毒副作用也极为敏感，因此面对此特殊人群临床用药需谨慎。本文采用实例探讨临床药师协助医生优化妊娠期、哺乳期的药物治疗方案，对静滴硫酸镁注射液的患者进行重点药学监护，为患者提供用药指导，并及时收集、上报药品不良反应等，保障了患者的用药安全，促进了临床用药的合理性与规范性。
위산기환자유우체내발생일계렬생리변화，회영향약물재체내적동역학개변，차용약후존재태반전운화유즙전운，가영향태인조직기관적발육급공능，신생인대약물적독부작용야겁위민감，인차면대차특수인군림상용약수근신。본문채용실례탐토림상약사협조의생우화임신기、포유기적약물치료방안，대정적류산미주사액적환자진행중점약학감호，위환자제공용약지도，병급시수집、상보약품불량반응등，보장료환자적용약안전，촉진료림상용약적합이성여규범성。
A wide range of physiological changes occur during perinatal period, these changes can significantly affect pharmacokinetics of drugs. The development and function of the tissue and organ in fetus can be inlfuenced after use of medicines in perinatal period patients because of placental transport and milk transport. Neonates are particularly sensitive to the toxic and side effect of most kinds of medicines. So the clinical use of drugs should be paid more attention to during perinatal period. In this article, the cases of pharmaceutical care by clinical pharmacists were discussed, such as assisting doctors to optimize the drug therapy regime for pregnant and lactational women, offering pharmaceutical care for patient with intravenous use of magnesium sulfate injection, providing medication education for patients, collecting the adverse drug reactions and so on. These measures ensure the safety of drug utilization in patients and promote the rational drug use in clinic.