CAJ | 학술논문

以姜黄素和马来酸酐为原料,经酯化、异构化、酰氯化和酯化合成了4个姜黄素衍生物。姜黄素衍生物c1~c4的收率分别为80.5%、83.7%、81.2%和85.4%,用IR,1 H NMR和13 C NMR确证了目标化合物的结构。并对c1~c4的抗氧化活性和抗菌活性进行了评价。结果表明,姜黄素衍生物 c1~c4清除 DPPH ·的 IC50分别为164.14±0．82、166.98±0.66、171.97±0.99和175.10±2.34 mg/L,它们的抗氧化活性均低于姜黄素(36.22±0.22 mg/L),姜黄素的酚羟基对抗氧化活性有重要影响。 c1~c4均具有良好的抗菌活性,其中化合物c4的抗菌活性最好, c4对金黄色葡萄球菌、大肠杆菌、青霉菌和黑曲霉菌的最小抑菌浓度(MIC)分别为0.5、0.5、0.25和1.0 g/L。α,β-不饱和羰基结构的化合物修饰姜黄素有望开发新的抗菌药物。
이강황소화마래산항위원료,경지화、이구화、선록화화지화합성료4개강황소연생물。강황소연생물c1~c4적수솔분별위80.5%、83.7%、81.2%화85.4%,용IR,1 H NMR화13 C NMR학증료목표화합물적결구。병대c1~c4적항양화활성화항균활성진행료평개。결과표명,강황소연생물 c1~c4청제 DPPH ·적 IC50분별위164.14±0．82、166.98±0.66、171.97±0.99화175.10±2.34 mg/L,타문적항양화활성균저우강황소(36.22±0.22 mg/L),강황소적분간기대항양화활성유중요영향。 c1~c4균구유량호적항균활성,기중화합물c4적항균활성최호, c4대금황색포도구균、대장간균、청매균화흑곡매균적최소억균농도(MIC)분별위0.5、0.5、0.25화1.0 g/L。α,β-불포화탄기결구적화합물수식강황소유망개발신적항균약물。
Four curcumin derivatives were synthesized from curucmin and maleic anhydride by esterification, isomerization, chlorination and esterification. The yields of curcumin derivatives c1-c4 were 80. 5%, 83. 7%, 81. 2% and 85. 4%, respectively. Their structures were confirmed by IR, 1 H NMR and 13 C NMR. The antioxidative and antibacterial activities of target compounds c1 -c4 were evaluated. The IC50 values for scavenging of DPPH·were 164. 14 ± 0. 82, 166. 98 ± 0. 66, 171. 97 ± 0. 99 and 175. 10 ± 2. 34 mg/L, respectively. Their antioxidative activity was lower than that of curcumin (36. 22 ± 0. 22 mg/L). This proved the importance of phenolic OH. The target compounds c1 -c4 displayed high antibacterial activity, especially compound c4. The minimal inhibiting concentration(MIC) of c4 against Staphylococcus aureus, Escherichia coli, Penicillium sp. and Aspergillus niger were 0. 5, 0. 5, 0. 25 and 1. 0 g/L, respectively. There is hope to obtain antibacterial candidates by curcumin modification with α,β-unsaturated carbonyl compounds.