CAJ | 학술논문

探讨丹瓜方对转基因糖尿病小鼠心脏组织的影响。32只A poE-/-小鼠数字随机等分为模型组、丹瓜方组、联合用药组（丹瓜方+吡格列酮）、吡格列酮组。喂以普通饲料，各组分别给药12周。小鼠处死，取心脏、匀浆，免疫组化测心脏血清反应因子（SR F）含量；解剖冠状动脉，光镜观察比较。结果：与模型组比较，联合用药组与丹瓜方组SR F阳性率降低有显著性差异（P＜0.01）；形态学观察，丹瓜方组与联合用药组冠状动脉内膜大部分无增厚。结果表明：丹瓜方对糖尿病小鼠心脏具有保护作用。
탐토단과방대전기인당뇨병소서심장조직적영향。32지A poE-/-소서수자수궤등분위모형조、단과방조、연합용약조（단과방+필격렬동）、필격렬동조。위이보통사료，각조분별급약12주。소서처사，취심장、균장，면역조화측심장혈청반응인자（SR F）함량；해부관상동맥，광경관찰비교。결과：여모형조비교，연합용약조여단과방조SR F양성솔강저유현저성차이（P＜0.01）；형태학관찰，단과방조여연합용약조관상동맥내막대부분무증후。결과표명：단과방대당뇨병소서심장구유보호작용。
To observe the effect of D an Gua-Fang on the heart of genetically induced diabetic mice. T hirty-tw o A poE-/-diabetic m ice w ere random ly divided into the m odel group, D an-gua prescription group, the com bined treatm ent group (Dan-gua prescription+ pioglitazone) and pioglitazone group. E ach group w as given m edicine respectively, and fed w ith norm al diet for 12 w eeks. T he heart hom ogenates production w as used to m easure related indicators. T he expression of SR F in heart hom ogenates w as detected by im m unohistochem ical. T he C oronary w as observed under light m icroscopy. C om pared w ith the m odel group, there w ere significant difference of SR F positive rate betw een com bination group and D an-gua prescription group (P<0.01). T he m orphology of D an-gua prescription group and the com bination group w as significantly im proved: m ost of the tunica intim a of the coronary artery cannot be found thickening. C om pared w ith the control group, Pioglitazone group's effect is w eaker,butbetterthan thatofthe untreated group.D an G ua-Fang hasprotective effecton the heartofdiabetic m ice.