传染病信息
傳染病信息
전염병신식
INFECTIOUS DISEASE INFORMATION
2014年
5期
286-288
,共3页
苑文雯%王晗%耿伟%朱剑功%李沛然%何叶莉%杨宁%李妍%郭桐生
苑文雯%王晗%耿偉%硃劍功%李沛然%何葉莉%楊寧%李妍%郭桐生
원문문%왕함%경위%주검공%리패연%하협리%양저%리연%곽동생
肝炎,慢性%降钙素%末期肝疾病%内毒素类
肝炎,慢性%降鈣素%末期肝疾病%內毒素類
간염,만성%강개소%말기간질병%내독소류
hepatitis,chronic%calcitonin%end stage liver disease%endotoxins
目的：探讨血清降钙素原（procalcitonin, PCT）和内毒素等常用炎症因子指标结合终末期肝病模型（model for end-stage liver disease, MELD）对慢性重症肝炎预后的预测价值。方法选取2011年1月-2013年12月慢性重症肝炎87例，入院24 h内检测PCT、内毒素、WBC计数、中性粒细胞（polymorphonuclear，PMN）计数和C-反应蛋白（C-reactin protein，CRP），同时进行MELD评分，并根据随访情况分为生存组和死亡组。结果单因素分析显示生存组PCT、CRP、MELD评分、WBC和PMN计数等显著低于死亡组，差异有统计学意义（P＜0.05），内毒素检测结果比较2组差异无统计学意义（P=0.620）。Logistic回归分析显示MELD评分、CRP、PCT和慢性重症肝炎死亡相关（P＜0.05）；CRP和MELD评分呈正相关，Spearman相关系数为0.69（P<0.05）；PCT和MELD评分呈正相关，Spearman相关系数为0.72（P<0.05）。结论 PCT和CRP纳入预测体系有可能提高重症肝炎预后的预测价值。
目的：探討血清降鈣素原（procalcitonin, PCT）和內毒素等常用炎癥因子指標結閤終末期肝病模型（model for end-stage liver disease, MELD）對慢性重癥肝炎預後的預測價值。方法選取2011年1月-2013年12月慢性重癥肝炎87例，入院24 h內檢測PCT、內毒素、WBC計數、中性粒細胞（polymorphonuclear，PMN）計數和C-反應蛋白（C-reactin protein，CRP），同時進行MELD評分，併根據隨訪情況分為生存組和死亡組。結果單因素分析顯示生存組PCT、CRP、MELD評分、WBC和PMN計數等顯著低于死亡組，差異有統計學意義（P＜0.05），內毒素檢測結果比較2組差異無統計學意義（P=0.620）。Logistic迴歸分析顯示MELD評分、CRP、PCT和慢性重癥肝炎死亡相關（P＜0.05）；CRP和MELD評分呈正相關，Spearman相關繫數為0.69（P<0.05）；PCT和MELD評分呈正相關，Spearman相關繫數為0.72（P<0.05）。結論 PCT和CRP納入預測體繫有可能提高重癥肝炎預後的預測價值。
목적：탐토혈청강개소원（procalcitonin, PCT）화내독소등상용염증인자지표결합종말기간병모형（model for end-stage liver disease, MELD）대만성중증간염예후적예측개치。방법선취2011년1월-2013년12월만성중증간염87례，입원24 h내검측PCT、내독소、WBC계수、중성립세포（polymorphonuclear，PMN）계수화C-반응단백（C-reactin protein，CRP），동시진행MELD평분，병근거수방정황분위생존조화사망조。결과단인소분석현시생존조PCT、CRP、MELD평분、WBC화PMN계수등현저저우사망조，차이유통계학의의（P＜0.05），내독소검측결과비교2조차이무통계학의의（P=0.620）。Logistic회귀분석현시MELD평분、CRP、PCT화만성중증간염사망상관（P＜0.05）；CRP화MELD평분정정상관，Spearman상관계수위0.69（P<0.05）；PCT화MELD평분정정상관，Spearman상관계수위0.72（P<0.05）。결론 PCT화CRP납입예측체계유가능제고중증간염예후적예측개치。
Objective To evaluate the prognostic value of procalcitonin (PCT)and common inflammatory markers combining the model for end-stage liver disease (MELD) score in patients with chronic severe hepatitis (CSH). Methods A total of 87 patients with CSH were collected from Jan. 2011 to Dec. 2013. Indexes of PCT, endotoxins, WBC, PMN, C-reactin protein (CRP) and MELD were determined within 24 h after the admission. According to the outcome, the 87 patients were divided into a survival group (n=51) and a death group (n=36). Results PCT, CRP, MELD score and PMN in survival group by single factor analysis were significantly lower than those in the death group (P<0.05). Binary logistic regression analysis indicated that MELD score, CRP and PCT highly correlated with the death of CSH. CRP was positively correlated with MELD score and Spearman's correlation coefficient was 0.69 (P<0.05). PCT was also positively correlated with the MELD, and Spearman's correlation coefficient was 0.72 (P<0.05). Conclusion Compared with the traditional prediction method, serum PCT and CRP can improve the ability to predict the prognosis for CSH.
