CAJ | 학술논문

百草枯是一种广泛使用的剧毒除草剂。因其便宜而且有效，在发展中国家大量使用，这让预防中毒很困难。百草枯中毒主要以自杀者口服多见，因其无特效解毒药，其致死率和致残率很高。早期多死于多器官功能衰竭，晚期多死于不可逆转的肺纤维化而致的呼吸衰竭。其有多种致损伤机制，治疗以综合治疗为主，最大程度地减少吸收和清除血浆中的百草枯负荷是治疗的首要措施。现就近年来百草枯致损伤机制和治疗方案的研究做一综述。
백초고시일충엄범사용적극독제초제。인기편의이차유효，재발전중국가대량사용，저양예방중독흔곤난。백초고중독주요이자살자구복다견，인기무특효해독약，기치사솔화치잔솔흔고。조기다사우다기관공능쇠갈，만기다사우불가역전적폐섬유화이치적호흡쇠갈。기유다충치손상궤제，치료이종합치료위주，최대정도지감소흡수화청제혈장중적백초고부하시치료적수요조시。현취근년래백초고치손상궤제화치료방안적연구주일종술。
Paraquat is an effective and widely used herbicide but also a lethal poison. In many developing countries paraquat is wide-ly available and inexpensive, making poisoning prevention difficult. However, most of the people poisoned by paraquat taken it as a means of suicide. Because of its no specific antidote,it leads to high mortality and disability rate. Early death is caused by multiple or-gan failure,and later ones by irreversible pulmonary fibrosis and respiratory failure. It has a variety of damage mechanism,so compre-hensive treatment is priority to given in treatment. Standard treatment for paraquat poisoning both prevents further absorption and re-duces the load of paraquat in the blood through haemoperfusion or haemodialysis. This paper reviews about the researches of paraquat injury mechanism and treatment in resent years.