CAJ | 학술논문

目的：观察表没食子儿茶素没食子酸酯( epigollatecatechin gallate,EGCG)对2型糖尿病大鼠血液生化指标的影响。方法：采用链脲佐菌素联合高脂饮食复制2型糖尿病大鼠模型,Wistar大鼠造模后随机分为正常对照组、模型对照组、EGCG大、中、小剂量[50、20、10 mg/(kg·d)]组治疗4周后。检测血清中门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆固醇( TCHO)、甘油三酯( TG)、尿素氮( UREA)、肌酐( CREA)变化。结果：与对照组比较,三组EGCG治疗组大鼠AST、ALT、UREA和CREA水平明显降低(P<0.05,P<0.01)；低浓度EGCG组对TCHO的影响无统计学差异(P>0.05),中、高浓度EGCG组TCHO、TG的影响有统计学意义(P<0.05)。结论： EGCG具有改善血脂紊乱,保护肝肾功能的作用。
목적：관찰표몰식자인다소몰식자산지( epigollatecatechin gallate,EGCG)대2형당뇨병대서혈액생화지표적영향。방법：채용련뇨좌균소연합고지음식복제2형당뇨병대서모형,Wistar대서조모후수궤분위정상대조조、모형대조조、EGCG대、중、소제량[50、20、10 mg/(kg·d)]조치료4주후。검측혈청중문동안산안기전이매(AST)、병안산안기전이매(ALT)、총담고순( TCHO)、감유삼지( TG)、뇨소담( UREA)、기항( CREA)변화。결과：여대조조비교,삼조EGCG치료조대서AST、ALT、UREA화CREA수평명현강저(P<0.05,P<0.01)；저농도EGCG조대TCHO적영향무통계학차이(P>0.05),중、고농도EGCG조TCHO、TG적영향유통계학의의(P<0.05)。결론： EGCG구유개선혈지문란,보호간신공능적작용。
Objective:To study the effects of epigallocatechin gallate( EGCG) on blood biochemical indexes of type 2 diabetes melli-tus(T2DM)rats. Methods:The combination of streptozotocin and high-fat diet was adopted to copy the model of T2DM. Wistar rats were randomly divided into model control group,diabetic model treated with EGCG[50,20,10 mg/(kg·d)]and normal control group. The changes of AST,ALT,TCHO,TG,UREA and CERA of serum were measured at the end of the 4th week. Results:Compared with the model group,the AST,ALT,UREA and CREA decreased significantly in the three EGCG groups. (P<0. 05,P<0. 01). There is no significant statistic difference of the influence on TCHO in the low concentration EGCG group(P>0. 05). There are significant statistic differences of the influence on TCHO and TG in the medium and high concentration EGCG groups(P<0. 05). Conclusion:EGCG can decrease blood lipid and protect liver and kidney.