CAJ | 학술논문

建立尿嘧啶替加氟片中替加氟和尿嘧啶的溶出度方法。采用转篮和浆法，以水为溶出介质，采用高效液相色谱法测定尿嘧啶替加氟片溶出度。结果表明，两种方法均可使尿嘧啶替加氟片二个组分很快溶出，30 min时二个组分的累积溶出量均达到75％以上，但方法之间存在差异。浆法更适合用于尿嘧啶替加氟片溶出度的测定。
건립뇨밀정체가불편중체가불화뇨밀정적용출도방법。채용전람화장법，이수위용출개질，채용고효액상색보법측정뇨밀정체가불편용출도。결과표명，량충방법균가사뇨밀정체가불편이개조분흔쾌용출，30 min시이개조분적루적용출량균체도75％이상，단방법지간존재차이。장법경괄합용우뇨밀정체가불편용출도적측정。
This paper established a test method for the dissolution of tegafur and uracil in compound tegafur tablets .Using basket and paddle method , the dissolution was tested by HPLC method , and the medium was water .The results indicated that tegafur and uracil in compound tegafur tablets were dissolved rapidly in two dissolution conditions , and the disso-lution rate of 30 min of all of the formations showed advantage than 75%of labeled amount . But they are a little diffrentent .The method of apparatus 2 was suitable for the determmina-tion of the dissolution of compound tegafur tablets .