中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
9期
138-140
,共3页
慢性肾衰竭%慢性心力衰竭%脑钠钛%C反应蛋白
慢性腎衰竭%慢性心力衰竭%腦鈉鈦%C反應蛋白
만성신쇠갈%만성심력쇠갈%뇌납태%C반응단백
Chronic renal failure%Chronic Heart failure%B-type natriuretic peptide%C-reactive protein
目的：探讨脑钠肽（BNP）及C反应蛋白（CRP）在慢性肾衰竭（CRF）并发慢性心力衰竭（CHF）患者中的诊断和判断预后的意义。方法选取CRF并发CHF患者40例作为观察组，CRF无CHF患者40例作为对照A组，另选取同期健康体检者40例作为对照B组，单纯CHF患者40例作为对照C组，检测并对比四组研究对象BNP、CRP水平及观察组患者在不同CKD分期、NYHA分级时BNP、CRP水平变化。结果观察组、对照C组患者BNP、CRP水平明显高于对照A组及对照B组，差异具有显著性（P＜0.05），对照A组与对照B组组间比较差异无显著性（P＞0.05），观察组与对照C组组间比较差异无显著性（P＞0.05）。观察组患者相同CKD分期，不同NYHA分级的BNP、CRP水平随心功能分级升高而明显升高，差异具有显著性（P＜0.05）；相同NYHA分级、不同CKD分期时BNP、CRP水平随CKD分期升高无明显升高，差异无显著性（P＞0.05）。结论血浆BNP、CRP水平检测对CRF并发CHF患者心功能的评估具有重要的临床意义。
目的：探討腦鈉肽（BNP）及C反應蛋白（CRP）在慢性腎衰竭（CRF）併髮慢性心力衰竭（CHF）患者中的診斷和判斷預後的意義。方法選取CRF併髮CHF患者40例作為觀察組，CRF無CHF患者40例作為對照A組，另選取同期健康體檢者40例作為對照B組，單純CHF患者40例作為對照C組，檢測併對比四組研究對象BNP、CRP水平及觀察組患者在不同CKD分期、NYHA分級時BNP、CRP水平變化。結果觀察組、對照C組患者BNP、CRP水平明顯高于對照A組及對照B組，差異具有顯著性（P＜0.05），對照A組與對照B組組間比較差異無顯著性（P＞0.05），觀察組與對照C組組間比較差異無顯著性（P＞0.05）。觀察組患者相同CKD分期，不同NYHA分級的BNP、CRP水平隨心功能分級升高而明顯升高，差異具有顯著性（P＜0.05）；相同NYHA分級、不同CKD分期時BNP、CRP水平隨CKD分期升高無明顯升高，差異無顯著性（P＞0.05）。結論血漿BNP、CRP水平檢測對CRF併髮CHF患者心功能的評估具有重要的臨床意義。
목적：탐토뇌납태（BNP）급C반응단백（CRP）재만성신쇠갈（CRF）병발만성심력쇠갈（CHF）환자중적진단화판단예후적의의。방법선취CRF병발CHF환자40례작위관찰조，CRF무CHF환자40례작위대조A조，령선취동기건강체검자40례작위대조B조，단순CHF환자40례작위대조C조，검측병대비사조연구대상BNP、CRP수평급관찰조환자재불동CKD분기、NYHA분급시BNP、CRP수평변화。결과관찰조、대조C조환자BNP、CRP수평명현고우대조A조급대조B조，차이구유현저성（P＜0.05），대조A조여대조B조조간비교차이무현저성（P＞0.05），관찰조여대조C조조간비교차이무현저성（P＞0.05）。관찰조환자상동CKD분기，불동NYHA분급적BNP、CRP수평수심공능분급승고이명현승고，차이구유현저성（P＜0.05）；상동NYHA분급、불동CKD분기시BNP、CRP수평수CKD분기승고무명현승고，차이무현저성（P＞0.05）。결론혈장BNP、CRP수평검측대CRF병발CHF환자심공능적평고구유중요적림상의의。
Objective To investigate the signiifcance of diagnosis and prognosis of brain natriuretic peptide (BNP) and C-reactive protein (CRP) in patients with chronic renal failure (CRF) complicated with chronic heart failure (CHF). Method Selected 40 patients of CRF with CHF as observation group;40 patients of CRF without CHF as control group A;40 healthy people as control group B;40 patients of CHF as control group C;tested and compared the levels of BNP and CRP in these four groups, and the changes of the levels of BNP and CRP in observation group in different period of CKD and NYHA. Result The levels of BNP and CRP in observation group and control group C were signiifcantly higher than those in control group A and group B, and there was signiifcant difference (P<0.05);there was no signiifcant difference between group A and B (P>0.05);there was no signiifcant difference between observation group and group C (P>0.05). In observation group, the patients’ BNP and CRP levels of the same CKD stage and different NYHA classiifcation increased obviously with the rise of heart function grade, and the difference was signiifcant (P<0.05);BNP and CRP levels of the same NYHA classiifcation and different CKD stages had no signiifcant rise with the rise of CKD stage, and there was no signiifcant difference (P>0.05). Conclusion The test of plasma BNP and CRP level has a great clinical signiifcance for the assessment of cardiac function of patients with CRF and CHF.
