中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
9期
45-48
,共4页
张朝红%黄玮%薛晓玲%王兰妮%孙晓丽
張朝紅%黃瑋%薛曉玲%王蘭妮%孫曉麗
장조홍%황위%설효령%왕란니%손효려
宫颈特殊染色法%上皮组织%宫颈癌病变
宮頸特殊染色法%上皮組織%宮頸癌病變
궁경특수염색법%상피조직%궁경암병변
FRD%Epithelial tissue%Cervical lesions
目的：探讨采用叶酸受体介导的宫颈特殊染色法（FRD）上皮组织特殊染色液对宫颈病变检查的临床价值，为早期及时发现宫颈病变提供参考依据。方法2014年1月至2014年4月联合全国14家医院随机对妇科门诊检查的2000例妇女进行筛查，行液基薄层细胞检测（TCT）、人乳头瘤病毒（HPV）、FRD染色检查，以病理组织学检查作为金标准，比较上述检测方法的诊断学评价标准。结果 FRD检出130例阳性患者，检出率为6.5%，灵敏度为83.06%，特异度为98.56%，漏诊率为16.94%，误诊率为1.44%，Kappa＝0.821，P＝0.000。TCT检出125例阳性患者，检出率为6.255%，灵敏度为86.29%，特异度为99.04%，漏诊率为13.71%，误诊率为0.96%，Kappa＝0.850，P＝0.000。HPV检出120例阳性患者，检出率为6.00%，灵敏度为79.84%，特异度为98.88%，漏诊率为20.16%，误诊率为1.12%，Kappa＝0.806，P＝0.000。三种检查方法检出率由高到低分别为FDR、TCT、HPV，但检出率比较差异无显著性（χ2＝0.427，P＝0.808）。结论三种检查方法的一致性比较TCT＞FRD＞HPV，但检出率比较差异无显著性，FRD与传统TCT、HPV检查具有相同的检出效能，但其具有更加方便、快速、经济的特点，值得作为一种快速筛检方法应用并推广。
目的：探討採用葉痠受體介導的宮頸特殊染色法（FRD）上皮組織特殊染色液對宮頸病變檢查的臨床價值，為早期及時髮現宮頸病變提供參攷依據。方法2014年1月至2014年4月聯閤全國14傢醫院隨機對婦科門診檢查的2000例婦女進行篩查，行液基薄層細胞檢測（TCT）、人乳頭瘤病毒（HPV）、FRD染色檢查，以病理組織學檢查作為金標準，比較上述檢測方法的診斷學評價標準。結果 FRD檢齣130例暘性患者，檢齣率為6.5%，靈敏度為83.06%，特異度為98.56%，漏診率為16.94%，誤診率為1.44%，Kappa＝0.821，P＝0.000。TCT檢齣125例暘性患者，檢齣率為6.255%，靈敏度為86.29%，特異度為99.04%，漏診率為13.71%，誤診率為0.96%，Kappa＝0.850，P＝0.000。HPV檢齣120例暘性患者，檢齣率為6.00%，靈敏度為79.84%，特異度為98.88%，漏診率為20.16%，誤診率為1.12%，Kappa＝0.806，P＝0.000。三種檢查方法檢齣率由高到低分彆為FDR、TCT、HPV，但檢齣率比較差異無顯著性（χ2＝0.427，P＝0.808）。結論三種檢查方法的一緻性比較TCT＞FRD＞HPV，但檢齣率比較差異無顯著性，FRD與傳統TCT、HPV檢查具有相同的檢齣效能，但其具有更加方便、快速、經濟的特點，值得作為一種快速篩檢方法應用併推廣。
목적：탐토채용협산수체개도적궁경특수염색법（FRD）상피조직특수염색액대궁경병변검사적림상개치，위조기급시발현궁경병변제공삼고의거。방법2014년1월지2014년4월연합전국14가의원수궤대부과문진검사적2000례부녀진행사사，행액기박층세포검측（TCT）、인유두류병독（HPV）、FRD염색검사，이병리조직학검사작위금표준，비교상술검측방법적진단학평개표준。결과 FRD검출130례양성환자，검출솔위6.5%，령민도위83.06%，특이도위98.56%，루진솔위16.94%，오진솔위1.44%，Kappa＝0.821，P＝0.000。TCT검출125례양성환자，검출솔위6.255%，령민도위86.29%，특이도위99.04%，루진솔위13.71%，오진솔위0.96%，Kappa＝0.850，P＝0.000。HPV검출120례양성환자，검출솔위6.00%，령민도위79.84%，특이도위98.88%，루진솔위20.16%，오진솔위1.12%，Kappa＝0.806，P＝0.000。삼충검사방법검출솔유고도저분별위FDR、TCT、HPV，단검출솔비교차이무현저성（χ2＝0.427，P＝0.808）。결론삼충검사방법적일치성비교TCT＞FRD＞HPV，단검출솔비교차이무현저성，FRD여전통TCT、HPV검사구유상동적검출효능，단기구유경가방편、쾌속、경제적특점，치득작위일충쾌속사검방법응용병추엄。
Objective To explore the use of cervical special staining of folate receptor mediated FRD clinical value of epithelial tissue special staining solution to inspect the cervical lesion, provide the method reference for the early detection of cervical lesions. Method From January 2014 to April 2014 jointed national hospital for a gynecological examination randomly 2000 cases of women screening, detection liquid based thin-layer cell line (TCT), human papilloma virus (HPV), FRD staining, theparts in pathology as the gold standard. Please check the histopathology as the gold standard, the diagnosis was the detection method of the evaluation standard. Result FRD detected 130 cases of patients with positive, positive rate was 6.5%;the sensitivity was 83.06%, speciifcity was 98.56%, the misdiagnosis rate was 16.94%, the misdiagnosis rate was 1.44%, Kappa=0.821, P=0.000. There were 125 cases of TCT positive patients, the positive rate was 6.255%;the sensitivity was 86.29%, speciifcity was 99.04%, the misdiagnosis rate was 13.71%, the misdiagnosis rate was 0.96%, Kappa=0.850, P=0.000. There were 120 cases of HPV positive patients, the positive rate was 6%;the sensitivity was 79.84%, speciifcity was 98.88%, the misdiagnosis rate was 20.16%, the misdiagnosis rate was 1.12%, Kappa = 0.806, P = 0.000. Three methods of inspection detection rate from high to low were FDR, TCT6, HPV, but the positive rate was not significantly difference (χ2 = 0.427, P = 0.808). Conclusion TCT > FRD > HPV consistency of three methods but the detection rate has no signiifcant difference, with the traditional TCT, HPV checks the same detection efifciency of the FRD detection method, but its characteristics with more convenient, fast, economy, worth as a rapid screening method for application.
