浙江预防医学
浙江預防醫學
절강예방의학
ZHEJIANG JOURNAL OF PREVENTIVE MEDICINE
2014年
10期
1002-1004,1012
,共4页
抗心磷脂抗体%脑梗死%复发
抗心燐脂抗體%腦梗死%複髮
항심린지항체%뇌경사%복발
Anti-cardiolipin antibodies%Cerebral infarction%Recurrence
目的：研究血清抗心磷脂抗体（ ACA）与复发性脑梗死的关系，为复发性脑梗死的预防和治疗提供依据。方法应用定量酶联免疫吸附实验（ ELISA）对初发脑梗死组120例、复发性脑梗死组110例及正常对照组150人进行血清 ACA 检测与比较。结果复发脑梗死组 ACA - IgG 阳性率（31.82%）高于初发脑梗死组（15.00%）（P<0.05）；脑梗死组和复发性脑梗死组ACA-IgG阳性率，年龄≤50岁者（57.89%）高于>50岁者（11.56%）（P<0.05）；ACA-IgG阳性率女性（23.53%）与男性（22.52%）比较差异无统计学意义（P>0.05）。追踪随访1年初发脑梗死ACA-IgG阳性者复发率（56.25%）明显高于阴性者复发率（29.79%）（ P<0.05）。结论复发性脑梗死患者血清ACA-IgG阳性率高，ACA-IgG阳性初发脑梗死患者复发率较高，ACA检测对于脑梗死的复发预测和临床早期干预具有重要意义。
目的：研究血清抗心燐脂抗體（ ACA）與複髮性腦梗死的關繫，為複髮性腦梗死的預防和治療提供依據。方法應用定量酶聯免疫吸附實驗（ ELISA）對初髮腦梗死組120例、複髮性腦梗死組110例及正常對照組150人進行血清 ACA 檢測與比較。結果複髮腦梗死組 ACA - IgG 暘性率（31.82%）高于初髮腦梗死組（15.00%）（P<0.05）；腦梗死組和複髮性腦梗死組ACA-IgG暘性率，年齡≤50歲者（57.89%）高于>50歲者（11.56%）（P<0.05）；ACA-IgG暘性率女性（23.53%）與男性（22.52%）比較差異無統計學意義（P>0.05）。追蹤隨訪1年初髮腦梗死ACA-IgG暘性者複髮率（56.25%）明顯高于陰性者複髮率（29.79%）（ P<0.05）。結論複髮性腦梗死患者血清ACA-IgG暘性率高，ACA-IgG暘性初髮腦梗死患者複髮率較高，ACA檢測對于腦梗死的複髮預測和臨床早期榦預具有重要意義。
목적：연구혈청항심린지항체（ ACA）여복발성뇌경사적관계，위복발성뇌경사적예방화치료제공의거。방법응용정량매련면역흡부실험（ ELISA）대초발뇌경사조120례、복발성뇌경사조110례급정상대조조150인진행혈청 ACA 검측여비교。결과복발뇌경사조 ACA - IgG 양성솔（31.82%）고우초발뇌경사조（15.00%）（P<0.05）；뇌경사조화복발성뇌경사조ACA-IgG양성솔，년령≤50세자（57.89%）고우>50세자（11.56%）（P<0.05）；ACA-IgG양성솔녀성（23.53%）여남성（22.52%）비교차이무통계학의의（P>0.05）。추종수방1년초발뇌경사ACA-IgG양성자복발솔（56.25%）명현고우음성자복발솔（29.79%）（ P<0.05）。결론복발성뇌경사환자혈청ACA-IgG양성솔고，ACA-IgG양성초발뇌경사환자복발솔교고，ACA검측대우뇌경사적복발예측화림상조기간예구유중요의의。
Objective To explore the relationship between serum anti - cardiolipin antibodies( ACA ) and recurrent cerebral infarction( RCI),and to provide the clinical evidence for the prevention and treatment of RCI. Methods One hundred and ten patients with RCI,120 patients with primary cerebral infarction( PCI)and 150 healthy controls were recruited. Serum ACA was detected using quantitative enzyme linked immunosorbent assay( ELISA)and the positive rate of ACA was compared between these three patient groups. Results The positive rate of serum ACA of RCI group (31. 82%)was higher than that of PCI group( 15. 00%)( P <0. 05 ). Compared with patients above 50 years old (11. 56%),the patients under age of 50 had a higher positive rate of ACA( 57. 89%)( P <0. 05 ). There was no significant difference between males( 22. 52%)and females( 23. 53%) in positive rate of ACA( P > 0. 05 ). The recurrence rate(56. 25%)of ACA positive patients was higher than that of ACA negative patients(29. 79%)after one year follow up(P<0. 05). Conclusion Higher positive rate of serum ACA is observed in RCI patients. The PCI patients with high positive rate of serum ACA has an increased susceptibility for RCI. ACA detection is important for prediction and clinical intervention of the recurrence of cerebral infarction.
