中国循环杂志
中國循環雜誌
중국순배잡지
CHINESE CIRCULATION JOURNAL
2014年
10期
776-779
,共4页
杨树涵%程劲松%刘艳宾%韩明磊%王成
楊樹涵%程勁鬆%劉豔賓%韓明磊%王成
양수함%정경송%류염빈%한명뢰%왕성
经皮冠状动脉介入治疗%肌钙蛋白I%曲美他嗪%不稳定性心绞痛%Tp-Te间期
經皮冠狀動脈介入治療%肌鈣蛋白I%麯美他嗪%不穩定性心絞痛%Tp-Te間期
경피관상동맥개입치료%기개단백I%곡미타진%불은정성심교통%Tp-Te간기
Percutaneous coronary intervention%Cardiac troponin I%Trimetazidine%Unstable angina pectoris%T-peak to T-end interval
目的：探讨经皮冠状动脉介入治疗（PCI）术前应用负荷剂量曲美他嗪60 mg对不稳定性心绞痛患者PCI术后Tp-Te间期的影响。方法：94例拟行PCI手术的不稳定性心绞痛患者分为曲美他嗪组和对照组。最终完成本研究的为曲美他嗪组34例和对照组42例，共76例。两组患者均接受常规药物治疗。曲美他嗪组在常规药物的基础上于PCI术前0.5~1.0 h一次性口服60 mg曲美他嗪。比较两组患者PCI术前后Tp-Te间期变化及术前、术后6 h、术后24 h血清肌酸激酶（CK）、肌酸激酶MB同工酶（CK-MB）和肌钙蛋白I（cTnI）水平以及术中室性心律失常情况。结果：曲美他嗪组和对照组两组术后Tp-Te间期均较术前缩短，但曲美他嗪组术后Tp-Te间期较对照组进一步缩短，差异均有统计学意义（P均<0.05）；两组术前Tp-Te间期差异无统计学意义（P>0.05）。术中对照组室性心律失常发生率（12.52%）高于曲美他嗪组（5.16%），差异有统计学意义（P<0.05）。曲美他嗪组CK、CK-MB、cTnI水平在术后6 h、24 h均较对照组低（P均<0.05）。结论：曲美他嗪可缩短不稳定性心绞痛患者PCI术后Tp-Te间期、预防室性心律失常，对PCI相关心肌损伤有保护作用。
目的：探討經皮冠狀動脈介入治療（PCI）術前應用負荷劑量麯美他嗪60 mg對不穩定性心絞痛患者PCI術後Tp-Te間期的影響。方法：94例擬行PCI手術的不穩定性心絞痛患者分為麯美他嗪組和對照組。最終完成本研究的為麯美他嗪組34例和對照組42例，共76例。兩組患者均接受常規藥物治療。麯美他嗪組在常規藥物的基礎上于PCI術前0.5~1.0 h一次性口服60 mg麯美他嗪。比較兩組患者PCI術前後Tp-Te間期變化及術前、術後6 h、術後24 h血清肌痠激酶（CK）、肌痠激酶MB同工酶（CK-MB）和肌鈣蛋白I（cTnI）水平以及術中室性心律失常情況。結果：麯美他嗪組和對照組兩組術後Tp-Te間期均較術前縮短，但麯美他嗪組術後Tp-Te間期較對照組進一步縮短，差異均有統計學意義（P均<0.05）；兩組術前Tp-Te間期差異無統計學意義（P>0.05）。術中對照組室性心律失常髮生率（12.52%）高于麯美他嗪組（5.16%），差異有統計學意義（P<0.05）。麯美他嗪組CK、CK-MB、cTnI水平在術後6 h、24 h均較對照組低（P均<0.05）。結論：麯美他嗪可縮短不穩定性心絞痛患者PCI術後Tp-Te間期、預防室性心律失常，對PCI相關心肌損傷有保護作用。
목적：탐토경피관상동맥개입치료（PCI）술전응용부하제량곡미타진60 mg대불은정성심교통환자PCI술후Tp-Te간기적영향。방법：94례의행PCI수술적불은정성심교통환자분위곡미타진조화대조조。최종완성본연구적위곡미타진조34례화대조조42례，공76례。량조환자균접수상규약물치료。곡미타진조재상규약물적기출상우PCI술전0.5~1.0 h일차성구복60 mg곡미타진。비교량조환자PCI술전후Tp-Te간기변화급술전、술후6 h、술후24 h혈청기산격매（CK）、기산격매MB동공매（CK-MB）화기개단백I（cTnI）수평이급술중실성심률실상정황。결과：곡미타진조화대조조량조술후Tp-Te간기균교술전축단，단곡미타진조술후Tp-Te간기교대조조진일보축단，차이균유통계학의의（P균<0.05）；량조술전Tp-Te간기차이무통계학의의（P>0.05）。술중대조조실성심률실상발생솔（12.52%）고우곡미타진조（5.16%），차이유통계학의의（P<0.05）。곡미타진조CK、CK-MB、cTnI수평재술후6 h、24 h균교대조조저（P균<0.05）。결론：곡미타진가축단불은정성심교통환자PCI술후Tp-Te간기、예방실성심률실상，대PCI상관심기손상유보호작용。
Objective: To explore the effect of trimetazidine (TMZ) on T-peak (Tp) to T-end (Te) interval of resting ECG in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Methods: We investigated 94 UAP patients with PCI and 76 of them ifnished the study as 2 groups. Control group,n=42, the patients received conventional treatment, and TMZ group,n=34, in addition to conventional treatment, the patients received TMZ 60 mg at 0.5 to 1 hour before PCI. The changes of Tp to Te interval before and after PCI were calculated, serum levels of creatine kinase (CK), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) at before and at 6, 24 hours after PCI were compared between 2 groups. Ventricular arrhythmia was recorded during PCI. Results: Both groups had shortened Tp to Te intervals after PCI, and TMZ group had more shortened Tp to Te interval, bothP<0.05, while the Tp to Te intervals were similar between 2 group before PCI,P>0.05. The occurrence rate of ventricular arrhythmia in Control group was higher than that in TMZ group (12.52% vs 5.16%) during PCI,P<0.05. Compared with Control group, TMZ group had lower levels of CK, CK-MB and cTnI at 6, 24 hours after PCI, allP<0.05. Conclusion: TMZ could decrease Tp to Te interval of resting ECG, prevent ventricular arrhythmia and reduce the relevant myocardial injury in UAP patients after PCI.
