CAJ | 학술논문

目的：比较五水头孢唑林钠和头孢唑林钠的稳定性。方法取注射用五水头孢唑林钠和2厂家生产的注射用头孢唑林钠进行胶塞倒置试验和振动试验，分别在灭菌注射用水和0．9％氯化钠注射液中溶解，用光学显微镜观察溶解过程。结果在胶塞倒置和振动试验中，显微镜下观察五水头孢唑林钠基本全部溶解，头孢唑林钠均有不同程度的药物未溶解。结论五水头孢唑林钠稳定性优于头孢唑林钠。
목적：비교오수두포서림납화두포서림납적은정성。방법취주사용오수두포서림납화2엄가생산적주사용두포서림납진행효새도치시험화진동시험，분별재멸균주사용수화0．9％록화납주사액중용해，용광학현미경관찰용해과정。결과재효새도치화진동시험중，현미경하관찰오수두포서림납기본전부용해，두포서림납균유불동정도적약물미용해。결론오수두포서림납은정성우우두포서림납。
Objective To investigate the difference of stability be-tween cefazolin sodium pentahydrate and amorphous cefazolin sodium. Methods Cefazolin sodium pentahydrate and amorphous cefazolin sodium from two manufacturers were processed rubber plug inverted test and vibration test, and then dissolved in the sterile water for injec-tion and 0.9% sodium chloride injection.The dissolving process was observed by an optical microscopy.Results In rubber plug inverted test and vibration test, cefazolin sodium pentahydrate almost was dis-solved while amorphous cefazolin sodium had different degrees of un-dissolved drugs by microscope observation.Conclusion The stability of cefazolin sodium pentahydrate is superior to that of amorphous ce-fazolin sodium.