CAJ | 학술논문

目的：研究四逆散冻干粉对大鼠睡眠的影响。方法将埋好记录电极的大鼠随机分为2组（每组15只），分别为四逆散冻干粉组（给药组）和空白组，每天保证给药组明暗交替12 h，术后恢复2 d 后，四逆散冻干粉4．95 g? kg-1连续灌胃给药7 d，空白组除灌胃给予蒸馏水外，其他处置方法同给药组。用脑电图分析并确定四逆散冻干粉对正常及失眠大鼠睡眠时相的影响。结果四逆散能延长正常与失眠大鼠的总睡眠时间，在睡眠时相上主要表现为延长慢波睡眠第2期（SWS2）和快速眼球运动睡眠（REMS），从而表明四逆散具有显著的改善睡眠作用。结论四逆散具有治疗失眠的作用。
목적：연구사역산동간분대대서수면적영향。방법장매호기록전겁적대서수궤분위2조（매조15지），분별위사역산동간분조（급약조）화공백조，매천보증급약조명암교체12 h，술후회복2 d 후，사역산동간분4．95 g? kg-1련속관위급약7 d，공백조제관위급여증류수외，기타처치방법동급약조。용뇌전도분석병학정사역산동간분대정상급실면대서수면시상적영향。결과사역산능연장정상여실면대서적총수면시간，재수면시상상주요표현위연장만파수면제2기（SWS2）화쾌속안구운동수면（REMS），종이표명사역산구유현저적개선수면작용。결론사역산구유치료실면적작용。
Objective To study on the effects of freeze -dry powder of Sini San on sleep in rats.Methods Rats were randomly divided into two groups (freeze -dry powder of Sini San and blank groups )of 15 each day to ensure the alternating light and dark 12 h.The postoperative recovery after two days, rats were continuously administered orally by freeze -dry powder of Sini San 4.95 g? kg-1 for 7 days.Blank group was given dis-tilled water by intragastric way.The other disposal methods were the same with administration group.The efficacy of Sini San on sleeping phase of normal and insomnious rats are carried out by electroencephalo -gram (EEG).Results The total sleeping time (TST) of rats were sig-nificantly prolonged induced by pentobarbital sodium , especially slow -wave sleep 2 (SWS2) and rapid -eye -movement sleep (REMS) were prolonged after the rats were orally administrated of Sini San freeze -dry powder for seven days.The result indicated that Sini San can significant effect on improving sleep.Conclusion There was the function of Sini San in the treatment for insomnia.