中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2014年
10期
889-891
,共3页
甘精胰岛素%阿卡波糖%老年糖尿病
甘精胰島素%阿卡波糖%老年糖尿病
감정이도소%아잡파당%노년당뇨병
insulin glargine%acarbose%elderly diabetes patient
目的:评价甘精胰岛素联用阿卡波糖治疗老年糖尿病患者的临床疗效及安全性。方法老年糖尿病患者120例随机分为治疗组和对照组,各60例。治疗组用甘精胰岛素联合阿卡波糖,对照组用精蛋白生物合成人胰岛素注射液联合阿卡波糖,胰岛素始剂量为0.15 U? kg-1,根据血糖水平调整胰岛素用量及口服药物用量,随访观察3个月。监测患者血糖水平,并记录不良事件;随访记录2组患者的血糖达标时间和每日胰岛素总量,计算日平均血糖,检测患者治疗后的糖化血红蛋白水平和空腹 C 肽值。结果治疗3个月后,患者的糖化血红蛋白、空腹血糖及日平均血糖水平较治疗前均降低(P <0.05),其中,治疗组的日平均血糖水平显著低于对照组(P <0.05)。治疗组的血糖达标时间和胰岛素日用量均少于对照组(P 均<0.05),治疗后空腹 C 肽含量明显高于对照组(P <0.05)。治疗组的不良反应发生率低于对照组(P <0.05)。结论甘精胰岛素联用阿卡波糖治疗老年糖尿病患者具有良好疗效,能快速、安全、有效地控制患者血糖。
目的:評價甘精胰島素聯用阿卡波糖治療老年糖尿病患者的臨床療效及安全性。方法老年糖尿病患者120例隨機分為治療組和對照組,各60例。治療組用甘精胰島素聯閤阿卡波糖,對照組用精蛋白生物閤成人胰島素註射液聯閤阿卡波糖,胰島素始劑量為0.15 U? kg-1,根據血糖水平調整胰島素用量及口服藥物用量,隨訪觀察3箇月。鑑測患者血糖水平,併記錄不良事件;隨訪記錄2組患者的血糖達標時間和每日胰島素總量,計算日平均血糖,檢測患者治療後的糖化血紅蛋白水平和空腹 C 肽值。結果治療3箇月後,患者的糖化血紅蛋白、空腹血糖及日平均血糖水平較治療前均降低(P <0.05),其中,治療組的日平均血糖水平顯著低于對照組(P <0.05)。治療組的血糖達標時間和胰島素日用量均少于對照組(P 均<0.05),治療後空腹 C 肽含量明顯高于對照組(P <0.05)。治療組的不良反應髮生率低于對照組(P <0.05)。結論甘精胰島素聯用阿卡波糖治療老年糖尿病患者具有良好療效,能快速、安全、有效地控製患者血糖。
목적:평개감정이도소련용아잡파당치료노년당뇨병환자적림상료효급안전성。방법노년당뇨병환자120례수궤분위치료조화대조조,각60례。치료조용감정이도소연합아잡파당,대조조용정단백생물합성인이도소주사액연합아잡파당,이도소시제량위0.15 U? kg-1,근거혈당수평조정이도소용량급구복약물용량,수방관찰3개월。감측환자혈당수평,병기록불량사건;수방기록2조환자적혈당체표시간화매일이도소총량,계산일평균혈당,검측환자치료후적당화혈홍단백수평화공복 C 태치。결과치료3개월후,환자적당화혈홍단백、공복혈당급일평균혈당수평교치료전균강저(P <0.05),기중,치료조적일평균혈당수평현저저우대조조(P <0.05)。치료조적혈당체표시간화이도소일용량균소우대조조(P 균<0.05),치료후공복 C 태함량명현고우대조조(P <0.05)。치료조적불량반응발생솔저우대조조(P <0.05)。결론감정이도소련용아잡파당치료노년당뇨병환자구유량호료효,능쾌속、안전、유효지공제환자혈당。
Objective To study the clinical curative effect and safety analysis of insulin glargine with acarbose treatment in elderly patients with diabetes.Methods A total of 120 cases of elderly patients with diabetes were randomly divided into two groups.The 60 patients of treat-ment group were treated with insulin glargine and acarbose combination , and the 60 patients of the control group were treated with isophane prota -mine biosynthetic human insulin injection and acarbose combination .The patient monitored blood glucose levels and recorded adverse events .The therapeutic time and the daily amount of insulin were recorded of two groups of patients.The average daily blood sugar were calculated and the HbA1c and fasting c -peptide values were detected at 3 months after treatment.Results The HbA1c, fasting glucose, and daily average blood glucose levels were lower than before treatment .The average daily blood sugar level of treatment group was obviously lower than the control group.The therapeutic time of treatment group patients was lower than the control group patients and the dosage of insulinwaslower in treatment group than control patients usage.The nocturnal hypoglycemia and gas-trointestinal reaction event occurrences of the medicine were lower than the control group.The fasting c -peptide levels was higher than control group after treatment .Conclusion There was a good therapeutic effect for elderly diabetes patients with insulin combination and acarbose , which can fast safe and effective control blood sugar of patients.