CAJ | 학술논문

目的：探讨微小MicroRNA 92a 在子宫内膜异位症及子宫正常内膜组织和血清中的表达量，分析其表达量和子宫内膜异位症相关的临床病理特征及意义。方法通过HE染色确定子宫内膜异位症后，应用实时定量PCR方法检测11例子宫内膜异位症患者及10例对照组的血液和组织中MicroRNA 92a的相对表达量。结果 MicroRNA 92a在子宫内膜异位症患者的组织和血清中表达量均明显低于对照组，差异均有统计学意义（P＜0.05）。结论 MicroRNA 92a的表达失调可能与子宫内膜异位症的发生发展有关，故对子宫内膜异位症的早期诊断、治疗及预后评估均具有一定的指导意义。
목적：탐토미소MicroRNA 92a 재자궁내막이위증급자궁정상내막조직화혈청중적표체량，분석기표체량화자궁내막이위증상관적림상병리특정급의의。방법통과HE염색학정자궁내막이위증후，응용실시정량PCR방법검측11례자궁내막이위증환자급10례대조조적혈액화조직중MicroRNA 92a적상대표체량。결과 MicroRNA 92a재자궁내막이위증환자적조직화혈청중표체량균명현저우대조조，차이균유통계학의의（P＜0.05）。결론 MicroRNA 92a적표체실조가능여자궁내막이위증적발생발전유관，고대자궁내막이위증적조기진단、치료급예후평고균구유일정적지도의의。
Objective To study the expression of MicroRNA 92a in the tiny disease and endometriosis uterine endometrial tissue and serum,analyzed its expression to clinicopathological features and significance of quantity and endometriosis related. Methods Determination of endometriosis by HE staining, the relative expression quantity of blood and tissues from 11 patients with endometriosis and 10 cases of control group by real-time quantitative PCR assay method is applied in MicroRNA 92a. Results MicroRNA 92a expression in patients with endometriosis tissue and serum were significantly lower than the control group,the differences were statistical y significant (P<0.05). Conclusion Expression of MicroRNA 92a disorders may be related to the occurrence and development of endometriosis,the endometriosis in early diagnosis,treatment and prognosis evaluation has certain guiding significance.