CAJ | 학술논문

骨髓基质干细胞在不同条件的诱导下，可以分化为成骨细胞、软骨细胞、成纤维细胞、脂肪细胞、神经细胞等多种细胞系，在骨髓微环境中骨和脂肪形成之间的关系是复杂的，成骨细胞与脂肪细胞均来源于骨髓基质干细胞（ MSCs），并且在其向成骨细胞和脂肪细胞分化之间存在相互逆转的关系和很大程度的可塑性。骨质疏松患者骨量减少与骨髓腔中脂肪组织增加有关，这可能与骨髓中MSCs分化失衡，过多向脂肪细胞分化有关。中医从“肾主骨”、“髓生骨”理论出发，认为肾精不足所致的骨髓空虚是骨质疏松症发病的关键，补肾中药通过影响骨髓基质干细胞成骨-成脂分化，从而防止骨质疏松症的发生。
골수기질간세포재불동조건적유도하，가이분화위성골세포、연골세포、성섬유세포、지방세포、신경세포등다충세포계，재골수미배경중골화지방형성지간적관계시복잡적，성골세포여지방세포균래원우골수기질간세포（ MSCs），병차재기향성골세포화지방세포분화지간존재상호역전적관계화흔대정도적가소성。골질소송환자골량감소여골수강중지방조직증가유관，저가능여골수중MSCs분화실형，과다향지방세포분화유관。중의종“신주골”、“수생골”이론출발，인위신정불족소치적골수공허시골질소송증발병적관건，보신중약통과영향골수기질간세포성골-성지분화，종이방지골질소송증적발생。
Under the different induction conditions, bone marrow mesenchymal stem cells ( MSCs) can differentiate to osteoblasts, chondrocytes, fibroblasts, adipocytes, and nerve cells.In the bone marrow microenvironment the relation between the bone and fat tissue formation is complicated. Both osteoblasts and adipocytes derive from MSCs. During the osteoblast and adipocyte differentiation, the possibility of transformation and plasticity exists.Bone mass loss in osteoporotic patients is associated with the increase of fat tissue in the bone marrow.It is related to imbalance of MSCs differentiation and to the over differentiation of adipocytes.According to the theory of Chinese medicine, the kidney governs bones and the marrow generates bones.It is believed that the deficiency of kidney essence is the key reason of osteoporosis. The kidney-tonifying medicine can influence the differentiation from MSCs to osteoblasts/adipocytes, therefore prevent the occurrence of osteoporosis.