CAJ | 학술논문

目的：研究辛伐他汀对绝经后伴血脂代谢异常女性跟骨骨密度的影响。方法分析885名绝经后口服辛伐他汀治疗血脂代谢异常（ TC＞5.18 mmol/L或LDL-C＞3.37 mmol/L）女性的跟骨骨密度，并依据T值分为骨质正常、骨量减少、骨质疏松。结果治疗前跟骨骨密度为305.3±59.2 mg/cm2，骨质正常、骨量减少、骨质疏松的人数分别为115、446、324，口服辛伐他汀（20 mg/d）治疗3月后骨密度为309.7±56.3 mg/cm2，骨质正常、骨量减少、骨质疏松的人数为117、459、319，12月后跟骨骨密度为312.5±60.9 mg/cm2，骨质正常、骨量减少、骨质疏松的人数为122、460、303。结论绝经后伴血脂代谢异常女性应用辛伐他汀（20 mg/d）治疗12个月后跟骨骨密度增高，但对骨质疏松患病风险无影响。
목적：연구신벌타정대절경후반혈지대사이상녀성근골골밀도적영향。방법분석885명절경후구복신벌타정치료혈지대사이상（ TC＞5.18 mmol/L혹LDL-C＞3.37 mmol/L）녀성적근골골밀도，병의거T치분위골질정상、골량감소、골질소송。결과치료전근골골밀도위305.3±59.2 mg/cm2，골질정상、골량감소、골질소송적인수분별위115、446、324，구복신벌타정（20 mg/d）치료3월후골밀도위309.7±56.3 mg/cm2，골질정상、골량감소、골질소송적인수위117、459、319，12월후근골골밀도위312.5±60.9 mg/cm2，골질정상、골량감소、골질소송적인수위122、460、303。결론절경후반혈지대사이상녀성응용신벌타정（20 mg/d）치료12개월후근골골밀도증고，단대골질소송환병풍험무영향。
Objective To evaluated the effect of simvastatin on bone mineral density ( BMD) of the calcaneus in postmenopausal women with hyperlipidemia.Methods BMD of the calcaneus of 885 postmenopausal women with hyperlipidemia ( TC>5.18 mmol/L or LDL-C>3.37 mmol/L) were studied.Simvastatin was used in these women.According to the T-score, normal bone mass, osteopenia, and osteoporosis were diagnosed.Results BMD of the calcaneus was 305.3 ± 59.2 mg/cm2 before the treatment.The number of people with normal bone mass, osteopenia, and osteoporosis were 115, 446, and 324, respectively.After simvastatin administration (20 mg/d) for 3 months, the BMD was 309.7 ±56.3 mg/cm2 .The number of people with normal bone mass, osteopenia, and osteoporosis were 117, 459, and 319, respectively.After a 12-month treatment, BMD of the calcaneus was 312.5 ±60.9 mg/cm2 .The number of people with normal bone mass, osteopenia, and osteoporosis were 122, 460, and 303, respectively.Conclusion After a 12-month simvastatin ( 20 mg/kg· d ) administration, BMD of the calcaneus increases in postmenopausal women with hyperlipidemia.It can not affect the risk of osteoporosis for these women.