中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2014年
10期
1230-1232,1239
,共4页
骨质疏松%IGF-1%IL-6%TNF-α%鲑鱼降钙素
骨質疏鬆%IGF-1%IL-6%TNF-α%鮭魚降鈣素
골질소송%IGF-1%IL-6%TNF-α%해어강개소
Osteoporosis%IGF-1%IL-6%TNF-α,Miacalcic
目的：研究鲑鱼降钙素对骨质疏松患者骨密度和体内细胞因子的影响。方法将本院60例骨质疏松患者随机分成两组，对照组30例口服钙尔奇D 1片/天，观察组30例在对照组治疗方案基础上加用鲑鱼降钙素。治疗前后检测两组患者第2-4腰椎和股骨颈骨密度（Bone mineral density，BMD）、胰岛素样生长因子-1（Insulin-like growth factor-1，IGF-1）、血清白细胞介素6（Interleukin-6，IL-6）、肿瘤坏死因子α（Tumor necrosis factor-α，TNF-α）的变化，观察患者临床症状的改善。结果（1）观察组第2-4腰椎和股骨颈BMD升高较对照组明显（P＜0.05）；（2）观察组患者IGF-1、IL-6以及TNF-α水平明显低于对照组（P＜0.01）；（3）观察组患者骨痛改善率高于对照组（P＜0.05）。（4）无论治疗组还是对照组的BMD均与IGF-1呈正相关，与IL-6和TNF-α呈负相关。结论鲑鱼降钙素可有效提升骨质疏松患者腰椎和股骨颈BMD，并能够改善IGF-1、IL-6以及TNF-α水平，有效缓解疼痛。
目的：研究鮭魚降鈣素對骨質疏鬆患者骨密度和體內細胞因子的影響。方法將本院60例骨質疏鬆患者隨機分成兩組，對照組30例口服鈣爾奇D 1片/天，觀察組30例在對照組治療方案基礎上加用鮭魚降鈣素。治療前後檢測兩組患者第2-4腰椎和股骨頸骨密度（Bone mineral density，BMD）、胰島素樣生長因子-1（Insulin-like growth factor-1，IGF-1）、血清白細胞介素6（Interleukin-6，IL-6）、腫瘤壞死因子α（Tumor necrosis factor-α，TNF-α）的變化，觀察患者臨床癥狀的改善。結果（1）觀察組第2-4腰椎和股骨頸BMD升高較對照組明顯（P＜0.05）；（2）觀察組患者IGF-1、IL-6以及TNF-α水平明顯低于對照組（P＜0.01）；（3）觀察組患者骨痛改善率高于對照組（P＜0.05）。（4）無論治療組還是對照組的BMD均與IGF-1呈正相關，與IL-6和TNF-α呈負相關。結論鮭魚降鈣素可有效提升骨質疏鬆患者腰椎和股骨頸BMD，併能夠改善IGF-1、IL-6以及TNF-α水平，有效緩解疼痛。
목적：연구해어강개소대골질소송환자골밀도화체내세포인자적영향。방법장본원60례골질소송환자수궤분성량조，대조조30례구복개이기D 1편/천，관찰조30례재대조조치료방안기출상가용해어강개소。치료전후검측량조환자제2-4요추화고골경골밀도（Bone mineral density，BMD）、이도소양생장인자-1（Insulin-like growth factor-1，IGF-1）、혈청백세포개소6（Interleukin-6，IL-6）、종류배사인자α（Tumor necrosis factor-α，TNF-α）적변화，관찰환자림상증상적개선。결과（1）관찰조제2-4요추화고골경BMD승고교대조조명현（P＜0.05）；（2）관찰조환자IGF-1、IL-6이급TNF-α수평명현저우대조조（P＜0.01）；（3）관찰조환자골통개선솔고우대조조（P＜0.05）。（4）무론치료조환시대조조적BMD균여IGF-1정정상관，여IL-6화TNF-α정부상관。결론해어강개소가유효제승골질소송환자요추화고골경BMD，병능구개선IGF-1、IL-6이급TNF-α수평，유효완해동통。
Objective To evaluate the effect of miacalcic on bone mineral density ( BMD ) and cytokines in the osteoporotic patients.Methods Sixty patients with osteoporosis were equally randomly assigned into 2 groups.Patients in control group ( 30 cases) received 600mg Caltrate per day.Patients in observation group (30 cases) received miacalcic besides Caltrate.The BMD of L2-4 lumbar spine and the femoral neck, insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6), and tumor necrosis factor-α( TNF-α) were determined before and after the treatment.Clinical symptoms were observed.Results BMD of the L2-4 lumbar spine and the femoral neck were higher in observation group than in control group (P<0.05).The serum levels of IGF-1, IL-6, and TNF-αwere lower in observation group than in control group (P<0.01).Pain was significantly relieved in the treatment group compared to control group (P<0.05).BMD change was positively correlated to IGF-1 but negatively correlated to IL-6 and TNF-αin both groups.Conclusion Miacalcic is effective to improve BMD and to relieve pain in patients with osteoporosis.It can improve the levels of IGF-1, IL-6, and TNF-α.It can effectively relieve pain.
