CAJ | 학술논문

目的：探讨老年人群低骨密度（包括骨质疏松和骨量减少）与冠心病的相关性。方法回顾性分析130例我院经冠脉造影确诊为冠心病的老年患者，根据检查结果，分为冠心病组及非冠心病组；根据双能X线骨密度仪检查结果分为骨质疏松组、骨量减少组和骨量正常组，比较三组间冠心病发病率的差异，进一步分析低骨密度与冠心病的关系。结果（1）冠心病组与非冠心病组在年龄、高血压病、吸烟、糖尿病、服用他汀类药物、血清肌酐、血高密度脂蛋白胆固醇＜40 mg/dL两组间比较均有显著性差异（ P＜0.01）；在体质指数（ BMI）、性别、冠心病家族史、服用影响骨密度的药物（钙剂、类固醇激素及双膦酸盐类）、血低密度脂蛋白胆固醇＞130 mg/dL、血清钙离子水平两组间比较均无统计学差异。（2）骨量减少组及骨质疏松组冠心病的发病率明显高于骨量正常组，3组间比较有统计学差异（ P＜0.01）。（3）与冠心病的危险因素比较，低骨密度、糖尿病、高血压的相对危险度分别为20.1、3.12、4.85。结论低骨密度组的冠心病发病率高于骨量正常组，低骨密度与冠心病的发病存在一定的相关性。
목적：탐토노년인군저골밀도（포괄골질소송화골량감소）여관심병적상관성。방법회고성분석130례아원경관맥조영학진위관심병적노년환자，근거검사결과，분위관심병조급비관심병조；근거쌍능X선골밀도의검사결과분위골질소송조、골량감소조화골량정상조，비교삼조간관심병발병솔적차이，진일보분석저골밀도여관심병적관계。결과（1）관심병조여비관심병조재년령、고혈압병、흡연、당뇨병、복용타정류약물、혈청기항、혈고밀도지단백담고순＜40 mg/dL량조간비교균유현저성차이（ P＜0.01）；재체질지수（ BMI）、성별、관심병가족사、복용영향골밀도적약물（개제、류고순격소급쌍련산염류）、혈저밀도지단백담고순＞130 mg/dL、혈청개리자수평량조간비교균무통계학차이。（2）골량감소조급골질소송조관심병적발병솔명현고우골량정상조，3조간비교유통계학차이（ P＜0.01）。（3）여관심병적위험인소비교，저골밀도、당뇨병、고혈압적상대위험도분별위20.1、3.12、4.85。결론저골밀도조적관심병발병솔고우골량정상조，저골밀도여관심병적발병존재일정적상관성。
Objective To investigate the relation between coronary heart disease ( CHD) and low bone mineral density( BMD, including osteoporosis and osteopenia) in the elderly.Methods A retrospective analysis of 130 elderly CHD patients diagnosed by coronary angiography was conducted in our hospital.According to the results, the patients were divided into CHD group and non-CHD group.In addition, the patients were divided into osteoporosis group, osteopenia group and the normal group based on BMD results by dual-energy X-ray absorptiometry.Difference of the incidence of CHD among the 3 groups was compared.The relationship between low BMD and CHD was further analyzed. Results 1 ) There were significant differences in age, hypertension, smoking, diabetes, statins, serum creatinine, and high-density lipoprotein cholesterol<40mg/dl between CHD and non-CHD group ( P <0.01 ) .There were no statistically significance between the two groups in the body mass index ( BMI ) , gender, family history of CHD, drugs affected BMD (calcium, steroids and bisphosphonates), low-density lipoprotein cholesterol>130mg/dl, and levels of serum calcium.2 ) The incidence of CHD in the osteopenia group and osteoporosis group was significantly higher than that in normal group, and the difference was statistically significant among the 3 groups ( P<0.01 ) .3 ) Compared with the traditional risk factors of CHD, the relative risks of low BMD, diabetes, hypertension were 20.1, 3.12, and 4.85, respectively.Conclusion The incidence of CHD in the low BMD groups is higher than that in normal group.There is a certain correlation between incidence of CHD and low BMD.