CAJ | 학술논문

骨肉瘤的早期诊断、复发与转移的预测以及避免化疗耐药已成为目前骨肉瘤治疗领域的关键。 DNA甲基化是导致癌基因激活和抑癌基因失活的主要原因，目前已证实多种基因的甲基化与骨肉瘤临床指标及靶向治疗密切相关，故有望用于骨肉瘤的临床诊治。文中就DNA甲基化与骨肉瘤关系的研究作一综述。
골육류적조기진단、복발여전이적예측이급피면화료내약이성위목전골육류치료영역적관건。 DNA갑기화시도치암기인격활화억암기인실활적주요원인，목전이증실다충기인적갑기화여골육류림상지표급파향치료밀절상관，고유망용우골육류적림상진치。문중취DNA갑기화여골육류관계적연구작일종술。
The early diagnosis , the prediction of recurrence and metastasis of osteosarcoma and avoiding chemotherapy resist -ance play a key role in the therapeutic areas of osteosarcoma .DNA methylation is the main reason of activation of oncogene and inacti-vation of tumor suppressor gene .It has been proven that the methylation of multiple genes is closely related to clinical indicators and targeted therapy of osteosarcoma .It is expected that DNA methylation can be used for the clinical diagnosis and treatment of osteosarco -ma.In this paper, the relationship between DNA methylation and osteosarcoma is reviewed .