CAJ | 학술논문

抑郁症患者治疗前后下丘脑、丘脑磁共振质子波谱分析
억욱증환자치료전후하구뇌、구뇌자공진질자파보분석
Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with depressive disorder before and after treatment

万方数据

实用放射学杂志實用放射學雜誌 실용방사학잡지
JOURNAL OF PRACTICAL RADIOLOGY
2014年 10期 1610-1613 ,共4页

杨睿%苟荣%燕浩%王鹏%袁莹%霍桢%杨军乐%李生斌%谢治椽%曾令霞%朱莹%邬小平

양예%구영%연호%왕붕%원형%곽정%양군악%리생빈%사치연%증령하%주형%오소평

磁共振波谱学%抑郁症%下丘脑%丘脑磁共振波譜學%抑鬱癥%下丘腦%丘腦
자공진파보학%억욱증%하구뇌%구뇌
magnetic resonance spectroscopy%depression%hypothalamus%thalamus

目的：通过对舍曲林治疗前后抑郁症患者下丘脑及丘脑的脑代谢变化的研究,寻找抑郁症的发病机制及可能的治疗方法。方法利用质子磁共振波谱分析技术(1 H-MRS)检测20例抑郁症患者丘脑及下丘脑的多个代谢指标。包括N-乙酰天门冬氨酸盐(NAA)、胆碱复合物(Cho)、肌酸(cr)、肌醇(mI)等。结果经舍曲林治疗后抑郁症患者的下丘脑 Cho、mI/Cr 值明显上升(P<0.05),与治疗前相比差异有统计学意义,丘脑在治疗前后的代谢指标无明显变化。结论下丘脑 mI/Cr 代谢异常可能是抑郁症患者的重要生化改变,mI有可能对抑郁症的治疗提供新的思路。
목적：통과대사곡림치료전후억욱증환자하구뇌급구뇌적뇌대사변화적연구,심조억욱증적발병궤제급가능적치료방법。방법이용질자자공진파보분석기술(1 H-MRS)검측20례억욱증환자구뇌급하구뇌적다개대사지표。포괄N-을선천문동안산염(NAA)、담감복합물(Cho)、기산(cr)、기순(mI)등。결과경사곡림치료후억욱증환자적하구뇌 Cho、mI/Cr 치명현상승(P<0.05),여치료전상비차이유통계학의의,구뇌재치료전후적대사지표무명현변화。결론하구뇌 mI/Cr 대사이상가능시억욱증환자적중요생화개변,mI유가능대억욱증적치료제공신적사로。
Objective To explore the neuronal mechanism of depression and potential treatment methods by investigating changes of metabolism in the thalamus and hypothalamus in patients with depressive disorder before and after taking sertraline Hydrochloride Tablets.Methods Several metabolites in the thalamus and hypothalamus were examined using proton magnetic resonance spectros-copy (1 H-MRS)on 20 patients with depressive disorder.The metabolites include N-acetylaspartate (NAA),Choline (Cho),Crea-tine (Cr)and Myo-Inositol (mI)etc.Results There were significant increase of Cho,ml/Cr in hypothalamus after the patients took sertraline Hydrochloride Tablets as treatment (P<0.05).However,no significant difference was observed for these metabolites in thalamus.Conclusion Abnormal metabolism of Cho,mI/Cr in hypothalamus could be an indicator of important biochemical changes in patients with depressive disorder.Change of mI might shed light in the treatment of depression.