浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
19期
1605-1607,1625
,共4页
王颖芳%杜红卫%吴红华%华丽%马大庆%谢素红%郑昭璟
王穎芳%杜紅衛%吳紅華%華麗%馬大慶%謝素紅%鄭昭璟
왕영방%두홍위%오홍화%화려%마대경%사소홍%정소경
系统性红斑狼疮%一级亲属%自身抗体谱
繫統性紅斑狼瘡%一級親屬%自身抗體譜
계통성홍반랑창%일급친속%자신항체보
Systemic lupus erythematosus%First- degree Relatives%Antinuclear antibodies
目的:了解金华地区系统性红斑狼疮(SLE)患者一级亲属抗核抗体谱的分布及意义。方法收集SLE患者一级亲属162例以及80例健康体检者,分别检测自身抗核抗体谱、相关免疫学指标情况,并进行统计。结果162例SLE患者一级亲属中,确诊为SLE 6例,3例为先证者母亲,2例为先证者姐妹,1例为先证者子女,其患病率为3.7%,同时确诊干燥综合征(SS)2例、混合型结缔组织病(MCTD)1例。剔除以上9例患者,其余153例“健康”一级亲属中ANA阳性15例(9.8%),抗Ro52阳性8例(5.2%),抗核小体阳性3例(2.0%),抗SSA阳性6例(3.9%),抗nRNP阳性9例(5.9%),抗心磷脂抗体IgG阳性11例(7.2%),抗心磷脂抗体IgM阳性3例(2.0%),抗ds- DNA阳性12例(7.8%);IgG升高10例(6.5%),IgM升高12例(7.8%),IgA升高3例(2.0%);补体C3下降9例(5.9%),补体C4下降6例(3.9%)。与健康对照组相比,SLE患者一级亲属中ANA、抗心磷脂抗体IgG、抗ds- DNA阳性率与健康对照组比较明显升高,差异均有统计学意义(均P<0.05),其余抗体及免疫球蛋白、补体的差异均无统计学意义(均P>0.05)。结论与正常人群相比,金华地区SLE患者一级亲属的ANA、抗心磷脂抗体IgG及抗ds- DNA阳性率明显升高,为狼疮的高危人群,需加强其筛查及随诊。
目的:瞭解金華地區繫統性紅斑狼瘡(SLE)患者一級親屬抗覈抗體譜的分佈及意義。方法收集SLE患者一級親屬162例以及80例健康體檢者,分彆檢測自身抗覈抗體譜、相關免疫學指標情況,併進行統計。結果162例SLE患者一級親屬中,確診為SLE 6例,3例為先證者母親,2例為先證者姐妹,1例為先證者子女,其患病率為3.7%,同時確診榦燥綜閤徵(SS)2例、混閤型結締組織病(MCTD)1例。剔除以上9例患者,其餘153例“健康”一級親屬中ANA暘性15例(9.8%),抗Ro52暘性8例(5.2%),抗覈小體暘性3例(2.0%),抗SSA暘性6例(3.9%),抗nRNP暘性9例(5.9%),抗心燐脂抗體IgG暘性11例(7.2%),抗心燐脂抗體IgM暘性3例(2.0%),抗ds- DNA暘性12例(7.8%);IgG升高10例(6.5%),IgM升高12例(7.8%),IgA升高3例(2.0%);補體C3下降9例(5.9%),補體C4下降6例(3.9%)。與健康對照組相比,SLE患者一級親屬中ANA、抗心燐脂抗體IgG、抗ds- DNA暘性率與健康對照組比較明顯升高,差異均有統計學意義(均P<0.05),其餘抗體及免疫毬蛋白、補體的差異均無統計學意義(均P>0.05)。結論與正常人群相比,金華地區SLE患者一級親屬的ANA、抗心燐脂抗體IgG及抗ds- DNA暘性率明顯升高,為狼瘡的高危人群,需加彊其篩查及隨診。
목적:료해금화지구계통성홍반랑창(SLE)환자일급친속항핵항체보적분포급의의。방법수집SLE환자일급친속162례이급80례건강체검자,분별검측자신항핵항체보、상관면역학지표정황,병진행통계。결과162례SLE환자일급친속중,학진위SLE 6례,3례위선증자모친,2례위선증자저매,1례위선증자자녀,기환병솔위3.7%,동시학진간조종합정(SS)2례、혼합형결체조직병(MCTD)1례。척제이상9례환자,기여153례“건강”일급친속중ANA양성15례(9.8%),항Ro52양성8례(5.2%),항핵소체양성3례(2.0%),항SSA양성6례(3.9%),항nRNP양성9례(5.9%),항심린지항체IgG양성11례(7.2%),항심린지항체IgM양성3례(2.0%),항ds- DNA양성12례(7.8%);IgG승고10례(6.5%),IgM승고12례(7.8%),IgA승고3례(2.0%);보체C3하강9례(5.9%),보체C4하강6례(3.9%)。여건강대조조상비,SLE환자일급친속중ANA、항심린지항체IgG、항ds- DNA양성솔여건강대조조비교명현승고,차이균유통계학의의(균P<0.05),기여항체급면역구단백、보체적차이균무통계학의의(균P>0.05)。결론여정상인군상비,금화지구SLE환자일급친속적ANA、항심린지항체IgG급항ds- DNA양성솔명현승고,위랑창적고위인군,수가강기사사급수진。
Objective To investigate the distribution of antinuclear antibodies level in first- degree relatives (FDR) of pa-tients with systemic lupus erythematosus (SLE). Methods Serum levels of antinuclear antibody and other autoantibodies were measured in 162 first- degree relatives of SLE patients and 80 healthy subjects in Jinhua region. Results Prevalence rate of SLE in first- degree relatives was 3.7%(6/162). Among remaining 152 non- SLE first- degree relatives, antinuclear antibody (ANA), anti- Ro52 antibody, anti- nucleosome, anti- Ro/SSA antibody, anti- nRNP antibody, anticardiolipin antibody (ACA)- IgG, ACA- IgM and anti- ds- DNA antibody were positive in 15 cases(9.8%), 8 cases (5.2%), 3 cases (2.0%), 6 cases (3.9%), 9 cas-es (5.9%), 11 cases(7.2%), 3 cases(2.0%), 12 cases(7.8%), respectively. Higher positive rate of ANA, (ACA)- IgG and an-ti- ds- DNA antibody were found in FDR of SLE patients than healthy control group (P<0.05). Conclusion The first- degree rel-atives of SLE patients have higher positive rate of ANA, (ACA)- IgG and anti- ds- DNA antibody, indicating high risk of SLE for FDRs.