CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病患者（chronic obstructive pulmonary disease，COPD）工作记忆的损伤。方法对46例COPD患者及与其人口学资料相匹配的30名健康对照被试（health controls，HC）进行空间、客体工作记忆测试，比较两组在工作记忆测试中正确率及反应时间的差异。结果 COPD组在空间工作记忆的正确率，空间、客体工作记忆的反应时均低于HC组[分别为：（85．40±11．40）％vs （93．33±5．20）％，（1293．62±205．72）ms vs （1042．41±197．90）ms，（1491．75±276．32）ms vs （1329．81±338．83）ms]，差异有统计学意义[分别为：t＝-3．725，P＜0．05；t＝5．438，P＜0．05；t＝2．336，P＜0．05）]。进一步研究发现，低氧血症COPD患者空间和客体工作记忆反应均时低于无低氧血症 COPD 患者[分别为：（1366．58±231．56）ms vs （1232．34±261．55）ms，（1592．35±282．42）ms vs （1407．24±245．76）ms]，差异有统计学意义[分别为：t＝-2．308，P＜0．05；t＝-2．377，P＜0．05]。COPD患者动脉血PaCO2值与空间工作记忆反应时具有负相关（r＝-3．796，P＜0．05）。结论 COPD患者存在空间工作记忆和执行功能的损伤，低氧血症COPD患者执行功能损伤更为严重。
목적：탐토만성조새성폐질병환자（chronic obstructive pulmonary disease，COPD）공작기억적손상。방법대46례COPD환자급여기인구학자료상필배적30명건강대조피시（health controls，HC）진행공간、객체공작기억측시，비교량조재공작기억측시중정학솔급반응시간적차이。결과 COPD조재공간공작기억적정학솔，공간、객체공작기억적반응시균저우HC조[분별위：（85．40±11．40）％vs （93．33±5．20）％，（1293．62±205．72）ms vs （1042．41±197．90）ms，（1491．75±276．32）ms vs （1329．81±338．83）ms]，차이유통계학의의[분별위：t＝-3．725，P＜0．05；t＝5．438，P＜0．05；t＝2．336，P＜0．05）]。진일보연구발현，저양혈증COPD환자공간화객체공작기억반응균시저우무저양혈증 COPD 환자[분별위：（1366．58±231．56）ms vs （1232．34±261．55）ms，（1592．35±282．42）ms vs （1407．24±245．76）ms]，차이유통계학의의[분별위：t＝-2．308，P＜0．05；t＝-2．377，P＜0．05]。COPD환자동맥혈PaCO2치여공간공작기억반응시구유부상관（r＝-3．796，P＜0．05）。결론 COPD환자존재공간공작기억화집행공능적손상，저양혈증COPD환자집행공능손상경위엄중。
Objective To observe the impairment of the working memory function in the patients with chronic obstructive pulmonary disease (COPD).Methods A total of 46 patients with chronic obstructive pulmonary disease were compared with 30 gender-,age -, years of education matched healthy controls (HC)on working memory tests about space and object,then the accurate rate and reaction time on these tasks between the two groups were compared.Results The accurate rate of the spatial working memory,reaction time on working memory tests about space and object of the COPD patients was worse than that of the HC group [(85.40 ±11.40)%vs (93.33 ±5.20)%;(1293.62 ±205.72)ms vs (1042.41 ±197.90)ms;(1491.75 ±276.32)ms vs (1329.81 ±338.83)ms respectively].The difference be-tween them showed statistical significance[(t=-3.725,P<0.001);(t=5.438,P<0.001);(t=2.336,P=0.022)respectively]. The difference in reaction time on working memory tests about space and object between patients with hypoxaemia groups and patients without hypoxaemia groups also showed statistical significance [(1366.58 ±231.56)ms vs (1232.34 ±261.55)ms;(1592.35 ±282.42)ms vs (1407.24 ±245.76)ms respectively](t=-2.308,P=0.026;t=-2.377,P=0.022 respectively).The study indicated the number of PaCO2 for COPD patients had negative correlation to reaction time about space working memory(r=-3.796,P=0.010).Conclusion The results suggest that patients with COPD exhibit space working memory and executive function impairment.The incidence of executive function dysfunction is higher in COPD patients with hypoxaemia.