CAJ | 학술논문

目的：测定灌胃炮天雄和刨附片对小鼠的急性毒性。方法：待禁食不禁水12h 后，各组24h 内一次性给药，其中刨附片、炮天雄组均分别灌胃刨附片水煎液25.2g 生药/kg 或炮天雄水煎液27.2g 生药/kg，正常对照组灌胃蒸馏水，给药体积均为40ml /kg，给药后观察并记录小鼠一般行为活动、体重、饮食及死亡等情况，连续观察14d。结果：刨附片组小鼠和炮天雄组小鼠无死亡，一般状态正常，无明显异常行为或变化，体重和摄食量逐日增长，与正常对照组比较，差异无统计学意义（P ＞0.05）。结论：刨附片、炮天雄水煎液灌胃小鼠均无明显急性毒性，最大给药量分别为25.2、27.2g 生药/kg，若按附子临床人用量为15g/日算，均大于人用量的100倍。
목적：측정관위포천웅화포부편대소서적급성독성。방법：대금식불금수12h 후，각조24h 내일차성급약，기중포부편、포천웅조균분별관위포부편수전액25.2g 생약/kg 혹포천웅수전액27.2g 생약/kg，정상대조조관위증류수，급약체적균위40ml /kg，급약후관찰병기록소서일반행위활동、체중、음식급사망등정황，련속관찰14d。결과：포부편조소서화포천웅조소서무사망，일반상태정상，무명현이상행위혹변화，체중화섭식량축일증장，여정상대조조비교，차이무통계학의의（P ＞0.05）。결론：포부편、포천웅수전액관위소서균무명현급성독성，최대급약량분별위25.2、27.2g 생약/kg，약안부자림상인용량위15g/일산，균대우인용량적100배。
objective To observe the acute toxicity of Pao tianxiong (PTX)and Pao fupian (PFP)with administration by gavage.Methods After fasting for 12h,the mice were given different drugs for once in 24h.The doses of PFP and PTX are 25.2g crude drug/kg (bw)and 27.2g crude drug/kg (bw).Mice in the control group was given distilled water.The given volume was 40ml/kg.Then,all the animals were monitored closely for 14 days on their normal behaviors,body weight,food consumption,death et al.Re-sults No death happened in both PTX -treated group and PFP -treated group;meanwhile,the behaviors,body weight and food con-sumptions in the drug -treated groups had no difference with the controlled group.Conclusion PFP and PTX don’t induce acute tox-icities on mice by gavage and the maximum doses are 25.2,27.2g/kg in crude medicinal,which are more than 100 times dose of Ac-oniti Lateralis Radix on adult human in clinic.