CAJ | 학술논문

目的：探讨子痫前期患者抗心磷脂抗体（ ACA）、抗β2糖蛋白Ⅰ（β2-GPⅠ）水平与妊娠结局的关系。方法选择轻度子痫前期组36例、重度子痫组28例、对照组32例，检测血ACA-IgM、ACA-IgG与抗（β2-GPⅠ）水平，并记录妊娠结局。结果重度前期组患者血清ACA-IgG、ACA-IgM、抗β2-GPⅠ水平显著高于轻度子痫前期组和对照组；轻度子痫前期组患者血清ACA-IgG、ACA-IgM、抗β2-GPⅠ水平显著高于对照组。早产的子痫前期患者血清ACA-IgG、ACA-IgM、抗β2-GPⅠ水平均显著高于足月产的子痫前期患者。胎儿生长受限的子痫前期患者血清ACA-IgM显著高于对照组，ACA-IgG、ACA-IgM、抗β2糖蛋白Ⅰ两两之间均存在显著的相关性（ P均<0.05）。结论抗心磷脂抗体与抗β2糖蛋白Ⅰ抗体参与了子痫前期的发生发展过程。
목적：탐토자간전기환자항심린지항체（ ACA）、항β2당단백Ⅰ（β2-GPⅠ）수평여임신결국적관계。방법선택경도자간전기조36례、중도자간조28례、대조조32례，검측혈ACA-IgM、ACA-IgG여항（β2-GPⅠ）수평，병기록임신결국。결과중도전기조환자혈청ACA-IgG、ACA-IgM、항β2-GPⅠ수평현저고우경도자간전기조화대조조；경도자간전기조환자혈청ACA-IgG、ACA-IgM、항β2-GPⅠ수평현저고우대조조。조산적자간전기환자혈청ACA-IgG、ACA-IgM、항β2-GPⅠ수평균현저고우족월산적자간전기환자。태인생장수한적자간전기환자혈청ACA-IgM현저고우대조조，ACA-IgG、ACA-IgM、항β2당단백Ⅰ량량지간균존재현저적상관성（ P균<0.05）。결론항심린지항체여항β2당단백Ⅰ항체삼여료자간전기적발생발전과정。
Objective To investigate the relationship of anti-cardiolipin antibodies,anti-β2 glycoproteinⅠlevels in preeclampsia and pregnancy outcomes. Methods 36 patients with mild preeclampsia group,28 patients with severe preeclampsia group and 32 patients in the con-trol group were selected into this study. Blood ACA-IgM,ACA-IgG and anti-β2-GP level Ⅰwere detected,and the outcome of pregnancy was recorded. Results Serum levels of ACA-IgG,ACA-IgM,anti-β2-GP Ⅰin severe preeclampsia group were significantly higher than that in mild preeclampsia and control groups. Serum ACA-IgG,ACA-IgM,anti-β2-GP Ⅰ levels in patients with mild preeclampsia were significantly higher than that of control group. Serum ACA-IgG ,ACA-IgM,anti-β2-GP Ⅰlevels in patients with preeclampsia at preterm delivery were significantly higher that of patients with preeclampsia at term production. Serum ACA-IgM was significantly higher in fetal growth restriction in preeclampsia. Among ACA-IgG,ACA-IgM,anti-β2-GPⅠ levels,this three had significant correlation between any two( P all<0. 05). Conclusion The anti-cardiolipin antibodies and anti-β2-GP Ⅰ antibody involved in the development and progression of pre-eclampsia.