CAJ | 학술논문

目的：探讨雷公藤多甙联合糖皮质激素对肾病综合征患者调节性T细胞（Treg）的影响和对该病的临床疗效。方法将46例原发性肾病综合征患者分为治疗组和对照组，各23例。治疗组采用雷公藤多甙联合糖皮质激素治疗，对照组单用糖皮质激素治疗，比较两组临床疗效、24 h尿蛋白定量、血清胆固醇、血清肌酐、血清蛋白、Treg等指标的变化。结果治疗组总有效率明显高于对照组，24 h尿蛋白定量、血清胆固醇、血清肌酐明显低于对照组，Treg和Treg/T细胞比值、血清蛋白明显高于对照组，差异均有统计学意义（P＜0.05）。结论雷公藤多甙联合糖皮质激素能通过上调Treg细胞比例、减少尿蛋白漏出、增加血清蛋白等，从而增加肾病综合征的临床缓解率。
목적：탐토뢰공등다대연합당피질격소대신병종합정환자조절성T세포（Treg）적영향화대해병적림상료효。방법장46례원발성신병종합정환자분위치료조화대조조，각23례。치료조채용뢰공등다대연합당피질격소치료，대조조단용당피질격소치료，비교량조림상료효、24 h뇨단백정량、혈청담고순、혈청기항、혈청단백、Treg등지표적변화。결과치료조총유효솔명현고우대조조，24 h뇨단백정량、혈청담고순、혈청기항명현저우대조조，Treg화Treg/T세포비치、혈청단백명현고우대조조，차이균유통계학의의（P＜0.05）。결론뢰공등다대연합당피질격소능통과상조Treg세포비례、감소뇨단백루출、증가혈청단백등，종이증가신병종합정적림상완해솔。
Objective To investigate the influence and clinical efficacy of Tripterygium glycosides combined with gluco-corticoid on regulatory T cells(Treg) of patients with nephritic syndrome(NS). Methods A total of 46 patients with primary nephrotic syndrome(PNS) were divided into treatment group and control group,23 cases in each group. The treatment group adopt-ed Tripterygium glycosides combined with glucocorticoid,while the control group only used glucocorticoid. The clinical efficacy, 24 h urine protein,serum cholesterol,serum creatinine,serum albumin,Treg and so on in the two groups were compared. Results The overall response rate,ratio of Treg and Treg/T cells and serum albumin in the treatment group were obviously higher than those in the control group,while the 24 h urine protein,serum cholesterol and serum creatinine were prominently lower than those in the control group,and differences all had statistical significance(P<0.05). Conclusion Tripterygium glycosides combined with glucocorticoid can up-regulate the ratio of Treg cells,reduce leak of urine protein,increase serum albumin and so on,so as to improve the remission rate of NC in clinic.