CAJ | 학술논문

目的：探讨重组人表皮生长因子在鼻咽癌放疗中预防放射性口咽炎的临床疗效。方法按照随机数字表法将本治疗组收治的64例鼻咽癌患者均分为实验组和对照组，实验组患者在放疗基础上加用重组人表皮生长因子口腔喷雾治疗，对照组患者在放疗基础上加用复方漱口液治疗，比较两组患者放射性口咽炎发生情况以及发生放射性口咽炎时平均放射剂量。结果实验组患者Ⅱ级+Ⅲ级放射性口咽炎发生率显著低于对照组，差异具有统计学意义（P＜0.05）；实验组患者发生Ⅰ级、Ⅱ级和Ⅲ级放射性口咽炎时平均放射剂量均显著高于对照组，差异具有统计学意义（P＜0.05）。结论重组人表皮生长因子能够有效预防鼻咽癌放疗中放射性口咽炎的发生，提高患者放疗剂量的耐受性，临床疗效显著。
목적：탐토중조인표피생장인자재비인암방료중예방방사성구인염적림상료효。방법안조수궤수자표법장본치료조수치적64례비인암환자균분위실험조화대조조，실험조환자재방료기출상가용중조인표피생장인자구강분무치료，대조조환자재방료기출상가용복방수구액치료，비교량조환자방사성구인염발생정황이급발생방사성구인염시평균방사제량。결과실험조환자Ⅱ급+Ⅲ급방사성구인염발생솔현저저우대조조，차이구유통계학의의（P＜0.05）；실험조환자발생Ⅰ급、Ⅱ급화Ⅲ급방사성구인염시평균방사제량균현저고우대조조，차이구유통계학의의（P＜0.05）。결론중조인표피생장인자능구유효예방비인암방료중방사성구인염적발생，제고환자방료제량적내수성，림상료효현저。
Objective To explore the preventive effect of the reorganization human epidermis growth factor in the prevention of radioactive oropharyngeal in the radiotherapy of nasopharyngeal carcinoma. Methods 64 cases of patients with nasopharyngeal carcinoma were randomly divided into experiment group and control group.On the basis of radiotherapy,the experiment group were treated by reorganization human epidermis growth factor,the control group were treated by mouthwashes.The happening of radio oropharyngeal and the average dose when radio oropharyngeal happened were compared in the two groups. Results The occurrence rate of II+III radio oropharyngeal in the experiment group was lower than the control group(P<0.05);The average dose when radio oropharyngeal happened in the experiment group were higher than the control group(P<0.05). Conclusion Reorganization human epidermal growth factor can effectively prevent the happening of the radioactive oropharyngeal in nasopharyngeal carcinoma radiotherapy,it can increase the tolerance of radiological dose for the patients.The clinical curative effect is distinct.