CAJ | 학술논문

目的：探讨喉鳞癌组织中血管内皮生长因子-C（ VEGF-C）及其受体VEGFR-3的表达以及与喉癌病理特征的关系。方法应用免疫组化SP法分别检测60例喉癌组织和32例癌旁组织中VEGF-C和VEGFR-3蛋白的表达情况，并分析二者表达强弱与喉鳞状细胞癌发生发展的相关关系。结果喉鳞癌组织中VEGF-C、VEGFR-3表达水平均显著高于相应癌旁组织（ P <0.05）；VEGF-C和VEGFR-3的表达在不同喉癌的分化程度、有无淋巴结转移及不同临床分期组间均有统计学意义（ P <0.05），而不同性别、年龄、吸烟史、肿瘤大小及临床分型组间差异均无统计学意义（ P >0.05）。结论 VEGF-C和VEGFR-3在喉癌的发展中起重要作用，二者的联合检测可作为喉癌是否有淋巴结转移及预后的预判指标。
목적：탐토후린암조직중혈관내피생장인자-C（ VEGF-C）급기수체VEGFR-3적표체이급여후암병리특정적관계。방법응용면역조화SP법분별검측60례후암조직화32례암방조직중VEGF-C화VEGFR-3단백적표체정황，병분석이자표체강약여후린상세포암발생발전적상관관계。결과후린암조직중VEGF-C、VEGFR-3표체수평균현저고우상응암방조직（ P <0.05）；VEGF-C화VEGFR-3적표체재불동후암적분화정도、유무림파결전이급불동림상분기조간균유통계학의의（ P <0.05），이불동성별、년령、흡연사、종류대소급림상분형조간차이균무통계학의의（ P >0.05）。결론 VEGF-C화VEGFR-3재후암적발전중기중요작용，이자적연합검측가작위후암시부유림파결전이급예후적예판지표。
Objective To explore the expression of VEGF-C and VEGFR-3 in laryngeal carcinoma tissue and the relationship between their expression and pathological features. Methods Immunohistochemical method had been used to detect the expression of VEGF-C and VEG-FR-3 in 60 specimens of laryngeal carcinoma and 32 specimens of para-carcinoma tissue. Results The expression of VEGF-C and VEGFR-3 in laryngeal carcinoma tissue was significantly higher than that of para-carcinoma tissue( P <0. 05). In laryngeal carcinoma,the expression of VEGF-C and VEGFR-3 was closely associated with the differentiation of carcinoma,metastasis in lymph nodes and clinical stages( P <0. 05), but their expression was independent of gender,age,smoking history,size of tumor and clinical classification( P >0. 05). Conclusion VEGF-C and VEGFR-3 may play an important role in the development of laryngeal carcinoma. The detection of VEGF-C and VEGFR-3 can be served as the prognostic indicator for metastasis in lymph nodes.