CAJ | 학술논문

目的：探讨抗核抗体（ANA）、干燥综合征A抗体（SSA）和干燥综合征B抗体（SSB）检测在原发性干燥综合征诊断中的临床意义。方法选择2012年1月至2013年12月期间收治220例原发性干燥综合征患者作为观察组，110例非原发性干燥综合征患者作为对照组，对两组人员进行ANA、SSA及SSB的检测，并进行比较。结果观察组患者SSA、SSB、SSA/SSB的检测阳性率明显高于对照组，差异有显著性（ P <0.05）；而两组ANA检测阳性率相比较，无显著性差异（ P >0.05）。结论 SSA、SSB及SSA/SSB检测在原发性干燥综合征诊断中，具有较强的特异性，值得临床推广应用。
목적：탐토항핵항체（ANA）、간조종합정A항체（SSA）화간조종합정B항체（SSB）검측재원발성간조종합정진단중적림상의의。방법선택2012년1월지2013년12월기간수치220례원발성간조종합정환자작위관찰조，110례비원발성간조종합정환자작위대조조，대량조인원진행ANA、SSA급SSB적검측，병진행비교。결과관찰조환자SSA、SSB、SSA/SSB적검측양성솔명현고우대조조，차이유현저성（ P <0.05）；이량조ANA검측양성솔상비교，무현저성차이（ P >0.05）。결론 SSA、SSB급SSA/SSB검측재원발성간조종합정진단중，구유교강적특이성，치득림상추엄응용。
Objective To explore clinical analysis of ANA,SSA and SSB detection in the diagnosis of primary Sjogrenˊs syndrome. Methods Total 220 cases of patients with primary Sjogrenˊs syndrome in our hospital were considered as observation group,while non primary Sjogrenˊs syndrome patients selected as control group. ANA,SSA and SSB in two groups were detected. Results In 220 cases of patients with pri-mary Sjogrenˊs syndrome,the positive rate of SSA,SSB and SSA/SSB in observation group were significantly higher than those in control group. The difference was statistically significant( P <0. 05). The positive rate of ANA has no difference between the two groups( P >0. 05). Con-clusion SSA,SSB and SSA/SSB detection in diagnosis of primary Sjogrenˊs syndrome showed specificity,so it is worth applying in clinic widely.