CAJ | 학술논문

目的：观察输注右美托咪定后对全麻患者气管插管时循环系统及丙泊酚用量的影响。方法 asaⅠ～Ⅱ，全身麻醉下行择期手术患者60例，随机分为生理盐水组(s组，n=30)和右美托咪定组(d组，n=30)。丙泊酚全麻诱导前10min，s组泵注生理盐水，d组患者静脉泵注右美托咪定0.6μg/kg。记录不同时间点的Hr和MaP，开始输注丙泊酚至意识消失所需时间，意识消失和插管时丙泊酚效应室靶浓度，以及插管时丙泊酚的用量。结果气管插管时d组患者Hr和MaP波动较s组小（P<0.05），d组泵注丙泊酚至意识消失所需时间较s组缩短（P<0.05），意识消失及插管时效应室靶浓度较s组降低（P<0.05），插管时丙泊酚用量较s组减少（P<0.05）。结论右美托咪定可有效地减轻气管插管时心血管反应，维持血液动力学稳定，并缩短丙泊酚诱导的插管时间和减少丙泊酚的用量。
목적：관찰수주우미탁미정후대전마환자기관삽관시순배계통급병박분용량적영향。방법 asaⅠ～Ⅱ，전신마취하행택기수술환자60례，수궤분위생리염수조(s조，n=30)화우미탁미정조(d조，n=30)。병박분전마유도전10min，s조빙주생리염수，d조환자정맥빙주우미탁미정0.6μg/kg。기록불동시간점적Hr화MaP，개시수주병박분지의식소실소수시간，의식소실화삽관시병박분효응실파농도，이급삽관시병박분적용량。결과기관삽관시d조환자Hr화MaP파동교s조소（P<0.05），d조빙주병박분지의식소실소수시간교s조축단（P<0.05），의식소실급삽관시효응실파농도교s조강저（P<0.05），삽관시병박분용량교s조감소（P<0.05）。결론우미탁미정가유효지감경기관삽관시심혈관반응，유지혈액동역학은정，병축단병박분유도적삽관시간화감소병박분적용량。
Objective To investigate the inlfuences of Dexmedetomidine (Dex) on cardiovascular system and propofol does in endotracheal intubation with the administration of general anesthesia. Methods 60 patients who were tested with asaⅠ-Ⅱand planed to undergoing surgeries with tracheal intubation anesthesia were randomly divided into two groups (Group s and Group d) of 30 cases each. 10 minutes before the induction of anesthesia, Group s patients were given 0.9%nacl intravenously 20ml, and Group d were given dex in a dose of 0.6ug.kg-1 intravenously. the patients’ heart rate (Hr) and mean arterial pressure (MaP) were recorded in different moments. also, how long did it take from propofol given intravenously to producing unconsciousness, the effector site concentration of propofol when patients were unconscious, and does of propofol when being in process of intubation were recorded. Results the change in Hr and MaP in Group d was varied within a smaller range than that in Group s(P<0.05).the time taken from propofol intravenously to producing unconsciousness was shorter in Group d than in Group s(P<0.05), the effector site concentration of propofol when patients are unconscious and the time during extubation in Group d were all lower than in Group s(P<0.05),the does of propofol was also decreased signiifcantly in Group d, compared with Group s(P<0.05).Conclusion dex can be attributed to decrease the circulating responses, keep hemodynamics stable. its actions also include shortening propofol induced endotracheal intubation time and reducing propofol dose.