CAJ | 학술논문

目的：研究探讨健脾和胃生肌散的制备工艺及对胃溃疡的应用效果。方法首先对健脾和胃生肌散的制备工艺进行探讨，在此基础上再对此进行临床效果的探讨，选择病例共140例，按随机数字表法分为治疗组和对照组各70例。对照组患者口服奥美拉唑胶囊40mg，每日1次，连服4周；治疗组在对照组基础上加服溃疡散每日2剂，早、晚饭前1h冲服，2周为1个疗程，一般连用2～3个疗程。结果治疗组总有效率为90%，对照组总有效率为74.3%，两组相比差异有显著性（P＜0.01）；两组治疗前后症状积分均有不同程度下降，显示显著性差异（P＜0.05），说明治疗组在改善症状方面优于对照组。治疗组、对照组HP阳性患者各有38例、34例，转阴率治疗组达到78.9%，对照组为61.8%，两组相比差异有显著性（P＜0.05）。结论本研究采用中西医联合治疗，不仅有杀灭HP、保护胃黏膜作用，而且具有活血化瘀之功能，能明显改善局部胃肠黏膜微循环，充分体现了中医药敷局部与调整体相结合治疗胃溃疡的优势，从整体上调整各脏腑生理功能，促进了溃疡愈合。
목적：연구탐토건비화위생기산적제비공예급대위궤양적응용효과。방법수선대건비화위생기산적제비공예진행탐토，재차기출상재대차진행림상효과적탐토，선택병례공140례，안수궤수자표법분위치료조화대조조각70례。대조조환자구복오미랍서효낭40mg，매일1차，련복4주；치료조재대조조기출상가복궤양산매일2제，조、만반전1h충복，2주위1개료정，일반련용2～3개료정。결과치료조총유효솔위90%，대조조총유효솔위74.3%，량조상비차이유현저성（P＜0.01）；량조치료전후증상적분균유불동정도하강，현시현저성차이（P＜0.05），설명치료조재개선증상방면우우대조조。치료조、대조조HP양성환자각유38례、34례，전음솔치료조체도78.9%，대조조위61.8%，량조상비차이유현저성（P＜0.05）。결론본연구채용중서의연합치료，불부유살멸HP、보호위점막작용，이차구유활혈화어지공능，능명현개선국부위장점막미순배，충분체현료중의약부국부여조정체상결합치료위궤양적우세，종정체상조정각장부생리공능，촉진료궤양유합。
Objective to investigate the preparation technology of strengthening spleen and stomach sarcogenic powder and its application effect on gastric ulcer. Methods first of all, the preparation of strengthening spleen and stomach sarcogenic powder was discussed, and also its clinical effect was explored on the basis of this study. a total of 140 cases, were randomly divided into treatment group and control group with 70 cases in each. Patients in the control group were given oral omeprazole capsules in a dose of 40mg, 1 time daily for 4 weeks, while patients in the treatment group were given oral ulcer powder, 2 agent daily, administered after dissolved before breakfast and dinner for 1h, 2 weeks for 1 courses, generally for 2-3 courses on the basis of treatment of the control group. Results the total effective rate of treatment group was 90%and total effective rate of the control group was 74.3%, there was signiifcant difference between two groups (P<0.01);in the two groups, symptom score before and after treatment decreased in varying degrees, showing signiifcant difference (P<0.05), indicating that the efifcacy of treatment group was better than that of control group in improving symptoms. the patients with HP positive in treatment group and the control group were 38 cases, 34 cases, respectively. the negative conversion ratio of treatment group reached 78.9%and 61.8%in the control group, there was signiifcant difference between two groups (P<0.05). Conclusion in this study, we adopted the combined treatment of chinese and Western medicine, which can not only kill HP, protecting gastric mucosa, but also has the function of promoting blood circulation to remove blood stasis. It can signiifcantly improve local gastrointestinal mucosal microcirculation and fully embodies advantages of combination of the local and the entirety adjustment of chinese medicine in treatment of gastric ulcer through adjusting the physiological function as a whole to promote the ulcer healing.