CAJ | 학술논문

目的：探讨分析新辅助化疗治疗乳腺癌的临床疗效。方法：回顾性分析2009年1月-2014年1月来本院就诊的123例乳腺癌患者的临床资料，通过ER、PR、C-erbB2等免疫指标的检测和影像学分析，所有的患者均给予DTC化疗方案治疗3~4个疗程，观察患者治疗后的临床疗效。结果：123例乳腺癌患者经过规律的化学治疗后，其中完全缓解53例（43.09%）、部分缓解49例（39.84%）、疾病稳定18例（14.63%），疾病进展3例（2.44%），治疗有效率为97.56%；不良反应主要为胃肠反应、粒细胞减少、转氨酶升高等，经过对症治疗后症状好转。结论：新辅助化疗治疗乳腺癌能够明显改善患者的术后疗效，增加保乳手术的机会，值得临床推广。
목적：탐토분석신보조화료치료유선암적림상료효。방법：회고성분석2009년1월-2014년1월래본원취진적123례유선암환자적림상자료，통과ER、PR、C-erbB2등면역지표적검측화영상학분석，소유적환자균급여DTC화료방안치료3~4개료정，관찰환자치료후적림상료효。결과：123례유선암환자경과규률적화학치료후，기중완전완해53례（43.09%）、부분완해49례（39.84%）、질병은정18례（14.63%），질병진전3례（2.44%），치료유효솔위97.56%；불량반응주요위위장반응、립세포감소、전안매승고등，경과대증치료후증상호전。결론：신보조화료치료유선암능구명현개선환자적술후료효，증가보유수술적궤회，치득림상추엄。
Objective:To investigate and analyze the clinical curative effect of neoadjuvant chemotherapy for the treatment of mammary cancer.Method:The clinical data of 123 patients with mammary cancer in our hospital from January 2009 to January 2014 were analyzed retrospectively,all patients reviewed by detection of ER,PR, C-erbB2 and other immune parameters and imaging analysis.Patients received 3-4 courses of treatment by DTC chemotherapy,and the clinical curative effect after treatment was observed.Result:In 123 mammary cancer patients after chemotherapy,53 patients(43.09%)were completely relieved,49 cases reached partial remission(39.84%),18 cases reached stable disease(14.63%)and 3 cases reached progression of disease(2.44%).The adverse reactions were mainly gastrointestinal reaction,granulocytopenia and transaminase eleations,all the symptoms were improved after symptomatic treatment.Conclusion:Neoadjuvant chemotherapy for the treatment of mammary cancer can significantly improve the postoperative curative effect of patients and increases the chances of breast conserving surgery,is worthy of clinical promotion.