CAJ | 학술논문

目的：探讨小剂量他达拉非治疗糖尿病勃起功能障碍（ED）的临床疗效。方法：选取2013年1月-2014年2月来本院男科门诊就诊的96例糖尿病ED患者，按照随机数字表法将其分为治疗组和对照组各48例，治疗组给予小剂量他达拉非5 mg，每晚睡前1 h口服，连续使用3个月；对照组口服六味地黄丸8粒，3次/d，连续服用3个月。控制血糖的措施照常进行，保持有规律的性生活。治疗前后查血尿常规、肝肾功能、血糖及心电图，进行IIEF-5评分，指导患者记录性生活日记。结果：两组治疗前后血尿常规、肝肾功能、心电图、血糖均无明显变化（P>0.05），治疗组治疗后IIEF-5评分、阴茎插入成功率及维持勃起完成性交成功率均明显高于治疗前及对照组，差异均有统计学意义（P<0.01），而对照组以上各指标治疗前后差异均无统计学意义（P>0.05）。两组均未出现严重不良反应。结论：小剂量他达拉非治疗糖尿病ED安全有效，值得临床推广。
목적：탐토소제량타체랍비치료당뇨병발기공능장애（ED）적림상료효。방법：선취2013년1월-2014년2월래본원남과문진취진적96례당뇨병ED환자，안조수궤수자표법장기분위치료조화대조조각48례，치료조급여소제량타체랍비5 mg，매만수전1 h구복，련속사용3개월；대조조구복륙미지황환8립，3차/d，련속복용3개월。공제혈당적조시조상진행，보지유규률적성생활。치료전후사혈뇨상규、간신공능、혈당급심전도，진행IIEF-5평분，지도환자기록성생활일기。결과：량조치료전후혈뇨상규、간신공능、심전도、혈당균무명현변화（P>0.05），치료조치료후IIEF-5평분、음경삽입성공솔급유지발기완성성교성공솔균명현고우치료전급대조조，차이균유통계학의의（P<0.01），이대조조이상각지표치료전후차이균무통계학의의（P>0.05）。량조균미출현엄중불량반응。결론：소제량타체랍비치료당뇨병ED안전유효，치득림상추엄。
Objective:To investigate the clinical effect of low-dose tadalafil in treatment of diabetic erectile dysfunction(ED).Method:96 diabetic erectile dysfunction patients in clinic of Andrology from January 2013 to February 2014 were selected,they were divided into the treatment group and the control group according to the random number table method,48 cases in each group.The treatment group was treated with low-dose tadalafil(5 mg,taken 1 h before sleeping every night)for 3 months.The control group was treated with Liuwei Dihuang Wan(8 pill,Tid)for 3 months.The treatment of diabetes mellitus was taken as usual,sexual life was kept regularly.Blood and urine routine,the function of liver and kidney,blood glucose,ECG and international index of erectile function-5(IIEF-5)score were measured before and after treatment.The patient was taught to write sexual encounter profile.Result:Before and after the treatment,there was no exchange of blood and urine routine,the function of liver and kidney,blood glucose,ECG between two groups(P>0.05),IIEF-5 score,success rate of sexual penetration and success of sexual in the treatment group after treatment were significantly higher than those in before treatment and control group,the differences were statistically significant(P<0.01),but no statistical significance in the change of IIEF-5 score,success rate of sexual penetration and success of sexual in the control group(P>0.05).The two groups were no serious adverse reaction. Conclusion:Low-dose tadalafil is safe and effective in the treatment of diabetic erectile dysfunction,is worthy of clinical promotion.