CAJ | 학술논문

凝集素(CLU)在肿瘤的发生和进展过程中起重要的抗肿瘤细胞坏死和抗凋亡作用，肿瘤细胞中不同亚型的CLU表达水平与肿瘤细胞的侵袭能力相关，肿瘤的发生发展与分泌型CLU(sCLU)过表达和核型 CLU(nCLU)缺失有关。它们在肿瘤组织中都有异常的表达，可作为多种恶性肿瘤和癌前病变的早期检测标志物，也可作为肿瘤预后评价的参考指标。本文将CLU与肿瘤关系的研究做一综述。
응집소(CLU)재종류적발생화진전과정중기중요적항종류세포배사화항조망작용，종류세포중불동아형적CLU표체수평여종류세포적침습능력상관，종류적발생발전여분비형CLU(sCLU)과표체화핵형 CLU(nCLU)결실유관。타문재종류조직중도유이상적표체，가작위다충악성종류화암전병변적조기검측표지물，야가작위종류예후평개적삼고지표。본문장CLU여종류관계적연구주일종술。
Clusterin (CLU) plays important role in anti-tumor necrosis and anti-apoptosis in the process of tumor oc-currence and progress. Different subtypes of CLU expression levels in cancer cells are correlated with the invasion a-bility of tumor cells. The occurrence and development of tumor are correlated with the sCLU overexpression and nCLU deficiency. They have abnormal expression in tumor tissue, can be used as early detection markers of a variety of ma-lignant tumor and precancerous lesions, also can be used as the reference indexes for evaluation of prognosis of tumor. This paper summarizes the relationship between CLU and cancer.