CAJ | 학술논문

目的：探讨缺血性脑卒中患者血浆肾素水平与服用阿司匹林致消化道出血的关系。方法收集重庆医科大学附属第二医院神经内科2012年6月至2012年12月服用阿司匹林的缺血性脑卒中患者50例，按血浆肾素水平分为两组，低肾素组包含21例，高肾素组29例。随访1年，以出现呕血、黑便症状、大便隐血为阳性，内镜示消化道溃疡出血或者死亡为终点事件，比较两组患者消化道出血发生情况。结果低肾素组患者平均年龄高于高肾素组（P＜0．05）；低肾素组患者的血压较高肾素组高（P＜0．05）；低肾素组的消化道出血率较高肾素组高（P＞0．05）。结论缺血性脑卒中者血浆肾素水平与服用阿司匹林后所致消化道出血无关。
목적：탐토결혈성뇌졸중환자혈장신소수평여복용아사필림치소화도출혈적관계。방법수집중경의과대학부속제이의원신경내과2012년6월지2012년12월복용아사필림적결혈성뇌졸중환자50례，안혈장신소수평분위량조，저신소조포함21례，고신소조29례。수방1년，이출현구혈、흑편증상、대편은혈위양성，내경시소화도궤양출혈혹자사망위종점사건，비교량조환자소화도출혈발생정황。결과저신소조환자평균년령고우고신소조（P＜0．05）；저신소조환자적혈압교고신소조고（P＜0．05）；저신소조적소화도출혈솔교고신소조고（P＞0．05）。결론결혈성뇌졸중자혈장신소수평여복용아사필림후소치소화도출혈무관。
Objective To investigate the relationship between plasma rennin levels in ischemic stroke patients and aspirin-in-duced gastrointestinal bleeding .Methods 50 ischemic stroke cases in neurology department of the Second Affiliated Hospital of Chongqing Medical University from June 2012 to December 2012 were collected and divided into 2 groups depended plasma rennin levels :low rennin group and high rennin group .Low rennin group contained 21 cases and high rennin group containd 29 cases .Ap-pearance of haematemesis ,melena and fecal occult blood were considered as positive identification ,peptic ulcer bleeding in endoscope or death as the endpoint event in 1 year follow-up .Comparison of the incidence of gastrointestinal bleeding between 2 groups was made .Results The average age of patients in low rennin group was higher than that in high rennin group(P<0 .05);blood pres-sure of patients in low rennin group was higher than that of high rennin group(P<0 .05);gastrointestinal bleeding rate of low ren-nin group was higher than that of high rennin group(P>0 .05) .Conclusion Different plasma rennin levels in ischemic stroke pa-tients may be unrelated to aspirin-induced gastrointestinal bleeding .