重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
29期
3921-3922,3925
,共3页
林一民%王云龙%何萌%刘兴明%黄晓林
林一民%王雲龍%何萌%劉興明%黃曉林
림일민%왕운룡%하맹%류흥명%황효림
前胶原%透明质酸%层粘连蛋白%胶原%肝硬化
前膠原%透明質痠%層粘連蛋白%膠原%肝硬化
전효원%투명질산%층점련단백%효원%간경화
procollagen%hyaluronic acid%laminin%collagen%liver cirrhosis
目的:探讨血清透明质酸(H A )、Ⅲ型前胶原(PCⅢ)、层粘连蛋白(L N )和Ⅳ型胶原(CⅣ)联合检测在肝纤维化诊断中的应用价值。方法采用放射免疫分析法对81例肝病患者(肝炎组24例,肝硬化组39例,肝癌组18例)和40名健康体检者(对照组)同时测定血清HA、PCⅢ、LN和CⅣ等4项指标水平,比较各组肝病和对照组间4项指标的差异及各组肝病间HA水平的变化。结果各组肝病患者血清肝纤维化4项指标水平均高于对照组(P<0.05或 P<0.01),肝硬化组织、肝癌组 HA水平明显高于肝炎组(P<0.05,P<0.01),肝癌组HA水平高于肝硬化组(P<0.05)。结论血清HA 、PCⅢ、LN、CⅣ联合检测对肝纤维化早期诊断和预后判断有重要临床意义。
目的:探討血清透明質痠(H A )、Ⅲ型前膠原(PCⅢ)、層粘連蛋白(L N )和Ⅳ型膠原(CⅣ)聯閤檢測在肝纖維化診斷中的應用價值。方法採用放射免疫分析法對81例肝病患者(肝炎組24例,肝硬化組39例,肝癌組18例)和40名健康體檢者(對照組)同時測定血清HA、PCⅢ、LN和CⅣ等4項指標水平,比較各組肝病和對照組間4項指標的差異及各組肝病間HA水平的變化。結果各組肝病患者血清肝纖維化4項指標水平均高于對照組(P<0.05或 P<0.01),肝硬化組織、肝癌組 HA水平明顯高于肝炎組(P<0.05,P<0.01),肝癌組HA水平高于肝硬化組(P<0.05)。結論血清HA 、PCⅢ、LN、CⅣ聯閤檢測對肝纖維化早期診斷和預後判斷有重要臨床意義。
목적:탐토혈청투명질산(H A )、Ⅲ형전효원(PCⅢ)、층점련단백(L N )화Ⅳ형효원(CⅣ)연합검측재간섬유화진단중적응용개치。방법채용방사면역분석법대81례간병환자(간염조24례,간경화조39례,간암조18례)화40명건강체검자(대조조)동시측정혈청HA、PCⅢ、LN화CⅣ등4항지표수평,비교각조간병화대조조간4항지표적차이급각조간병간HA수평적변화。결과각조간병환자혈청간섬유화4항지표수평균고우대조조(P<0.05혹 P<0.01),간경화조직、간암조 HA수평명현고우간염조(P<0.05,P<0.01),간암조HA수평고우간경화조(P<0.05)。결론혈청HA 、PCⅢ、LN、CⅣ연합검측대간섬유화조기진단화예후판단유중요림상의의。
Objective To explore the application value of combined detection of serum hyaluronic acid(HA) ,procollagen type Ⅲ(PCⅢ) ,laminin(LN) and collagen type Ⅳ(CⅣ) .Methods Immunoradiometric analysis was conclucted to detet the index levels of serum HA ,PC Ⅲ ,LN and C Ⅳ in 81 patients with liver disease(24 cases in hepatitis group ,39 cases in liver cirrhosis group ,18 ca-ses in liver cancer group) and 40 healthy adult(control group) .Then compared the differences of 4 indicators among groups .Results Four index levels of serum liver fibrosis from liver disease patients were higher than those of control group(P< 0 .05 or P<0 .01) ,HA level of liver cirrhosis group and liver cancer group were significantly higher than that in hepatitis group (P<0 .05 ,P<0 .01)HA level of liver cancer group was higher than that of liver cirrhosis group(P<0 .05) ,liver cirrhosis was higher than hepati-tis group(P<0 .05) .Conclusion Combined determination of the serum HA ,PCⅢ ,LN and CⅣ has importantly clinical significance in early diagnosis and prognosis of hepatic fibrosis .