重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
29期
3887-3889
,共3页
白幸%吴素华%冉伟%梅浙川
白倖%吳素華%冉偉%梅浙川
백행%오소화%염위%매절천
幽门螺杆菌%快速尿素酶试验%13 C呼气试验%幽门螺杆菌粪便抗原
幽門螺桿菌%快速尿素酶試驗%13 C呼氣試驗%幽門螺桿菌糞便抗原
유문라간균%쾌속뇨소매시험%13 C호기시험%유문라간균분편항원
helicobacter pylori%rapid urease test%13 C-urea breath test%helicobacter pylori stool antigen
目的：探讨3种幽门螺杆菌（HP）检测方法的临床价值，寻找更适合临床推广的快速 HP检测方法。方法对该院行胃镜检查的109例患者，分别用多点、多部位胃黏膜取材行快速尿素酶试验（RUT）、13C呼气试验（13C-UBT）及 HP粪便抗原（HpSA）免疫快检卡检测 HP感染，比较其检测效果。结果两块胃黏膜（胃窦＋胃体）RUT阳性率为34．86％，高于单块胃黏膜（胃窦或胃体）、两块胃黏膜（胃体），差异均有统计学意义（P＜0．05）；以13 C-UBT为“金标准”诊断 HP感染，两块胃黏膜（胃窦＋胃体）敏感性、准确性分别为72．97％、80．73％，高于两块胃黏膜（胃窦），低于四块胃黏膜（两块胃窦＋两块胃体）。RU T、13 C-UBT及HpSA免疫快检卡阳性率两两间比较差异均无统计学意义（P＞0．05）；以13 C-UBT为“金标准”诊断 HP感染，HpSA免疫快检卡敏感性、特异性、准确性分别为86．49％、95．83％、92．66％，均高于RU T。结论两块胃黏膜（胃窦＋胃体）取材是更适合临床推广的RUT取材方案。RUT、13 C-UBT 及HpSA免疫快检卡均为临床快速HP检测的可靠方法，但HpSA免疫快检卡更适合临床推广。
目的：探討3種幽門螺桿菌（HP）檢測方法的臨床價值，尋找更適閤臨床推廣的快速 HP檢測方法。方法對該院行胃鏡檢查的109例患者，分彆用多點、多部位胃黏膜取材行快速尿素酶試驗（RUT）、13C呼氣試驗（13C-UBT）及 HP糞便抗原（HpSA）免疫快檢卡檢測 HP感染，比較其檢測效果。結果兩塊胃黏膜（胃竇＋胃體）RUT暘性率為34．86％，高于單塊胃黏膜（胃竇或胃體）、兩塊胃黏膜（胃體），差異均有統計學意義（P＜0．05）；以13 C-UBT為“金標準”診斷 HP感染，兩塊胃黏膜（胃竇＋胃體）敏感性、準確性分彆為72．97％、80．73％，高于兩塊胃黏膜（胃竇），低于四塊胃黏膜（兩塊胃竇＋兩塊胃體）。RU T、13 C-UBT及HpSA免疫快檢卡暘性率兩兩間比較差異均無統計學意義（P＞0．05）；以13 C-UBT為“金標準”診斷 HP感染，HpSA免疫快檢卡敏感性、特異性、準確性分彆為86．49％、95．83％、92．66％，均高于RU T。結論兩塊胃黏膜（胃竇＋胃體）取材是更適閤臨床推廣的RUT取材方案。RUT、13 C-UBT 及HpSA免疫快檢卡均為臨床快速HP檢測的可靠方法，但HpSA免疫快檢卡更適閤臨床推廣。
목적：탐토3충유문라간균（HP）검측방법적림상개치，심조경괄합림상추엄적쾌속 HP검측방법。방법대해원행위경검사적109례환자，분별용다점、다부위위점막취재행쾌속뇨소매시험（RUT）、13C호기시험（13C-UBT）급 HP분편항원（HpSA）면역쾌검잡검측 HP감염，비교기검측효과。결과량괴위점막（위두＋위체）RUT양성솔위34．86％，고우단괴위점막（위두혹위체）、량괴위점막（위체），차이균유통계학의의（P＜0．05）；이13 C-UBT위“금표준”진단 HP감염，량괴위점막（위두＋위체）민감성、준학성분별위72．97％、80．73％，고우량괴위점막（위두），저우사괴위점막（량괴위두＋량괴위체）。RU T、13 C-UBT급HpSA면역쾌검잡양성솔량량간비교차이균무통계학의의（P＞0．05）；이13 C-UBT위“금표준”진단 HP감염，HpSA면역쾌검잡민감성、특이성、준학성분별위86．49％、95．83％、92．66％，균고우RU T。결론량괴위점막（위두＋위체）취재시경괄합림상추엄적RUT취재방안。RUT、13 C-UBT 급HpSA면역쾌검잡균위림상쾌속HP검측적가고방법，단HpSA면역쾌검잡경괄합림상추엄。
Objective To discuss the clinical value of three kinds of helicobacter pylori (HP) detection methods and find out the appropriate method for clinical application of the HP detection .Methods A total of 109 patients received gastroscopy ,the efficacy of RUT ,13C-urea breath test(13C-UBT) and the immunoCard STAT helicobacter pylori stool antigen (HpSA) for detection of HP were compared .Results RUT positive rate of the two pieces of gastric mucosa (the gastric antrum and the gastric body) was 34 .86% ,higher than that of single piece of gastric mucosa (gastric antrum or stomach body ) and two pieces of gastric mucosa (stomach) ,the difference was statistically significant (P<0 .05);The diagnosis of HP infection was based on 13 C-UBT ,sensitivity and accuracy of the two pieces of gastric mucosa (the gastric antrum and the gastric body) were 72 .97% and 80 .73% ,respectively , higher than that of two pieces of gastric mucosa and gastric antrum ,and lower than the four pieces of gastric mucosa (two pieces of gastric antrum + two pieces of the gastric body) .There was no statistically significant difference among RUT ,13 C-UBT and the immunoCard STAT HpSA(P>0 .05) .The diagnosis of HP infection was based on 13C-UBT ,the immunoCard STAT HpSA sensi-tivity ,specificity and accuracy were 86 .49% ,95 .83% ,92 .66% ,respectively ,which were higher than RUT .Conclusion Two pieces of gastric mucosa (the gastric antrum and the gastric body) materials is appropriate for clinical promotion RUT based solution . RUT ,13C-UBT and hpsas immune quick check card are all clinical detection of HP and reliable methods ,but hpsas immune quick check card is more suitable for clinical promotion .
