CAJ | 학술논문

目的：对比研究典型症状与非典型症状的非糜烂反流病（NERD）患者胃组织白细胞介素-1β（IL-1β）的差异及临床意义。方法 N ERD 患者70例，按照有无典型反流症状，分为2个亚型：典型症状组43例、非典型症状组27例；采用化学发光法评估不同亚型N ERD患者胃组织中IL-1β的表达差异。结果与非典型症状组比较，典型症状组IL-1β水平明显降低，差异有统计学意义[（75．26±7．20） pg/mL vs ．（107．22±13．13） pg/mL ，P＝0．039]。结论典型症状和非典型症状的NERD患者胃组织IL-1β有明显差异，提示 IL-1β可能参与了不同亚型的NERD发生的机制。
목적：대비연구전형증상여비전형증상적비미란반류병（NERD）환자위조직백세포개소-1β（IL-1β）적차이급림상의의。방법 N ERD 환자70례，안조유무전형반류증상，분위2개아형：전형증상조43례、비전형증상조27례；채용화학발광법평고불동아형N ERD환자위조직중IL-1β적표체차이。결과여비전형증상조비교，전형증상조IL-1β수평명현강저，차이유통계학의의[（75．26±7．20） pg/mL vs ．（107．22±13．13） pg/mL ，P＝0．039]。결론전형증상화비전형증상적NERD환자위조직IL-1β유명현차이，제시 IL-1β가능삼여료불동아형적NERD발생적궤제。
Objective To study the differences and its clinical significance of the expression of interleukin 1-beta (interleukin 1 beta ,IL-1 beta) between the patients with typical symptoms and atypical symptoms of non-erosive reflux diseases(NERD) in the stomach tissue .Methods 70 cases of patients with NERD were divided into two subtypes according to the presence or absence of typical reflux symptoms ,the typical group (43 cases) ,and the atypical symptoms group (27 cases);The interleukin-1 assay kit (chemiluminescence) was applied to assess the differences of IL-1βin stomach tissue of NERD patients with different subtypes .Re-sults Compared with the atypical symptoms group ,the concentration of IL-1 beta in typical symptoms group was obviously lower and the difference was statistically significant [(75 .26 ± 7 .20) pg/mL vs .(107 .22 ± 13 .13) pg/mL ,P=0 .039] .Conclusion Significant differences of the expression of IL-1βin the stomach tissue were found between the typical symptoms group and the a-typical symptoms group ,suggesting that IL-1βmay be involved in the occurrence of different subtypes of NERD .